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Review Article

微波诱导绿色合成:高效开发生物活性嘧啶支架的可持续技术

卷 30, 期 9, 2023

发表于: 23 September, 2022

页: [1029 - 1059] 页: 31

弟呕挨: 10.2174/0929867329666220622150013

价格: $65

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摘要

在杂环化合物的合成过程中，采用微波辐射作为加热源。微波诱导合成的加热机制包括偶极极化和离子传导。这种加热技术遵循绿色协议，因为它涉及到在合成过程中使用可回收的有机溶剂。微波加热方法具有反应速度快、反应过程简单、产品收率高、纯度高、减少环境污染等优点。因此，微波加热是一种可持续高效生产杂环类化合物嘧啶的技术。嘧啶是一种六元含氮杂环化合物，由于多种治疗应用而发挥着重要作用。这部分是产生具有不同生物活性的候选药物的基本组成部分，包括抗癌(卡培他滨)、抗甲状腺(丙基硫脲嘧啶)、抗组胺(培咪罗last)、抗疟疾(乙胺嘧啶)、抗糖尿病(四氧嘧啶)、抗高血压(米诺地尔)、抗炎(八氯替胺)、抗真菌(cyprodinil)、抗菌(磺胺甲嗪)等。本文就微波辐射技术下嘧啶类似物的合成及其治疗潜力进行了综述。

关键词: 生物活性，发展，绿色合成，微波，嘧啶，可持续。

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