Title:Periodontal Film: A Potential Treatment Strategy for Periodontitis
Volume: 12
Issue: 3
Author(s): Debabrata Ghosh Dastidar*, Avinandan Ash, Debjani Saha, Poulomi Chakraborty and Prosun Tribedi
Affiliation:
- Department of Pharmaceutics, Guru Nanak Institute of Pharmaceutical Science & Technology, Kolkata, India
Keywords:
Periodontitis, biofilm, antibiotics, nanoparticles, gum infection, periodontal film.
Abstract: Periodontitis is a serious gum infection associated with inflammation of the periodontium
around the teeth. Based on the etiology and pathogenesis, periodontitis has several conventional
treatment strategies. Treatment with antibiotics and antimicrobials is the most common therapy.
However, the development of drug resistance and the manifestation of side effects make conventional
strategies ineffective. In recent decades, local drug delivery in the periodontal pocket has
gained significant attention as a novel strategy. Sustained drug release at the target site (periodontal
pocket) for a prolonged period is the main advantage over conventional therapy. Bioadhesive periodontal
films are mostly used. They are thin films made up of unique mixtures of bioadhesive polymers,
binders, plasticizers, and drug release modifiers. They can be loaded with antibiotics, metal
nanoparticles, metal oxide nanoparticles, or a combination. The dried film is cut into a suitable size
and inserted into the periodontal pocket for direct delivery of therapeutic agents. Thus, a smaller
dose is required, and systemic side effects are avoided. In this manuscript, the pathophysiology of
periodontitis, the role of biofilm formation, development of periodontal film loaded with antibiotics
and nanoparticles have been reviewed, and the future aspects have been discussed.
