Title:Potential Plant Secondary Metabolites for the Prevention of Skin Cancers
and their Mechanism: A Review
Volume: 9
Issue: 4
Author(s): Jai Parkash Kadian*, Madan Lal Kaushik*, Bhupendra Chauhan and Aniruddh Dev Singh
Affiliation:
- Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University Gangoh, Saharanpur (UP), 247341, India
- Adarsh Vijendra Institute of Pharmaceutical Sciences, Shobhit University Gangoh, Saharanpur (UP), 247341, India
Keywords:
Plant derived, metabolites, skin carcinoma, cell lines, phytochemicals, anticarcinogenic, melanoma.
Abstract: Skin carcinoma is the most common malignancy, including malignant melanoma and
non-malignant melanoma throughout the world, and in the last three decades, its incidences have
been increasing drastically. High cost, severe side effects and development of resistance from conventional
chemotherapy have decreased its acceptability and increased the urge for the search for
alternate options. Therefore, plant derived phytochemicals have come up with cost effectiveness,
ease of availability and promising potential for skin related cancers. In spite of the lack of clinical
data involving humans to support the positive effects of phytochemicals on different types of skin
cancers, topical application of these plant derived anticancer phytochemicals is extremely promising.
Many mechanisms and pathways underlie the antitumor activity of plant-derived phytochemicals
, such as loss of mitochondrial membrane potential, the release of cytochrome-c, suppression of
antiapoptotic proteins and induction of proapoptotic proteins, activation of caspases, Fas, FADD and
p53 signaling pathway, inhibition of Akt signaling pathway, phosphorylation of ERK, P13K, Raf,
survivin gene, STAT 3 and NF-kB. The use of cell line models in the in vitro study of skin cancer
offers the opportunity to identify the mechanisms of action of plant derived phytochemicals against
various types of skin cancer. As such, this article aims at providing a comprehensive review of plant
extracts and phytochemicals, which have been reported to exhibit promising anti-carcinogenic properties
in animal models and against various skin cancer cell lines.