Title:Satisfaction with Social Roles and Physical Function in Immune-mediated
Inflammatory Diseases: A Cross-Sectional Study
Volume: 17
Issue: 3
Author(s): Rocco Spagnuolo*, Francesco Salvatore Iaquinta, Daniele Mauro, Ilenia Pantano, Stefano Dastoli, Saverio Naty, Cristina Cosco, Rosellina Margherita Mancina, Daniela Iacono, Emanuela Gaggiano, Annarita Ruggiero, Steven Paul Nisticò, Francesco Ciccia, Rosa Daniela Grembiale and Doldo Patrizia
Affiliation:
- Department of Clinical and Experimental Medicine, Magna Graecia University of Catanzaro, Calabria, Catanzaro,
Italy
Keywords:
Immune-mediated inflammatory diseases, PROMIS, inflammatory bowel disease, inflammatory arthritis, psoriasis, physical function, social satisfaction.
Abstract:
Background: Although mood disorders have been well characterized by immunemediated
inflammatory diseases, physical function and satisfaction with social roles have not yet
been defined as independent domains.
Objective: The study aims to assess satisfaction with social roles and physical function alterations in a
population with immune-mediated inflammatory diseases and identify associated characteristics.
Methods: Physical function and social role satisfaction were evaluated through the Patientreported
Outcomes Measurement System. Besides comparison between groups, univariate and
multivariable logistic regression analyses were performed to identify independent predictors.
Results: Two hundred sixty-five patients with immune-mediated inflammatory diseases and 206 controls
were recruited. Compared to controls, patients with inflammatory bowel diseases had impaired
physical function (p<0.001), while patients with inflammatory arthritis reported impairment in both
domains (p<0.001, each). In the univariate logistic regression, gender, high school educational level,
physical activity, and occupation were positively associated with physical function and social role
satisfaction (p<0.001; p=0.001; p<0.001; p=0.001 and p<0.001; p=0.012; p=0.008; p=0.004, respectively).
Active disease and steroids were inversely associated with physical function and social roles
satisfaction (p=0.033; p=0.022 and p=0.002; p=0.038, respectively). Further associations were found
between age and physical function (p=0.002) and biological treatment and ESR with social roles satisfaction
(p<0.001; p=0.043; respectively). In the multivariable regression, gender was found to be
associated with physical function (p<0.001) and social roles satisfaction (p=0.003). Negatively associated
factors were biological treatment for satisfaction with social roles (p<0.001) and steroids for
physical function (p=0.021), and social roles satisfaction (p=0.018).
Conclusion: Immune-mediated inflammatory diseases determine alterations in physical function
and social life satisfaction. Gender and treatment are independently associated factors. Patientreported
outcomes should be considered in clinical management to define patients’ real needs.