Title:An Immune-Suppressive Triterpenoid from the Roots of Kadsura coccinea
Volume: 19
Issue: 12
Author(s): Jiaxin Tian, Kunyu Li, Guanghai Ma, Gang Chen and Feng Gao*
Affiliation:
- Department of Pharmacy, China Academy of Chinese Medical Sciences, Xiyuan Hospital, Beijing, China
- Heibei Bai-
CaoKangShen Pharmaceutical Co., Ltd., Heibei, China
Keywords:
Triterpenes, immune suppression, Kadsura coccinea, secolanostane, rheumatoid arthritis, TCMs.
Abstract: Kadsura coccinea is a folk medicine from the family Schisandraceae. Clinically, it has been
used to treat many diseases like chronic gastritis and rheumatoid arthritis (RA). Lignans and triterpenes
are the main constituents of it. In this paper, phytochemical research on the root of K. coccinea was
carried out, leading to the isolation of a previously undescribed 3,4-secolanostane (1). Its structure was
established by means of comprehensive spectral analysis, including ECD calculation. Furthermore,
bioactivity assay revealed that 1 could elicit a moderate immune-suppressive activity, showing an IC50
value of 8.32 ± 0.13 μM against ConA-induced T-cell proliferation and with IC50 value of 15.58 ± 0.25
μM against LPS-induced B-cell proliferation. The results indicate that 1 might be used in the treatment
of rheumatic diseases.
