Title:An Updated Account on Formulations and Strategies for the Treatment of Burn
Infection – A Review
Volume: 28
Issue: 18
Author(s): Mohit Kumar, Syed Mahmood and Uttam Kumar Mandal*
Affiliation:
- Department of Pharmaceutical Sciences and Technology, Maharaja Ranjit Singh Punjab Technical University (MRSPTU),
Bathinda, 151001, Punjab, India
Keywords:
Microbial agent, wound healing, drug delivery, hydrogel, nanoparticles, nanofibre.
Abstract:
Background: Burn injury is considered one of the critical injuries of the skin. According to WHO
(World Health Organization), approximately 3,00,000 deaths are caused each year mainly due to fire burns,
with additional deaths attributed to heat and other causes of burn e.g., electric devices, chemical materials, radioactive
rays, etc. More than 95% of burn injuries occur in developing countries.
Introduction: Burn injuries have been a prominent topic of discussion in this present era of advancements.
Burns is one of the common and devastating forms of trauma. Burn injuries are involved in causing severe
damage to skin tissues and various other body parts triggered particularly by fire, blaze, or exposure to chemicals
and heated substances. They leave a long-lasting negative impact on the patients in terms of their physical
and mental health.
Methods: The various methods and bioactive hydrogels, a viable and widely utilised approach for treating
chronic wounds, remain a bottleneck. Many traditional approaches such as woven material, conventional antimicrobial
agents, hydrogel sheets, and creams are utilised in wound healing. Nowadays, lipid-based nanoparticles,
nanofibres systems, and foam-based formulations heal the wound.
Result: The prepared formulation showed wound healing activity when tested on rat model. The nanofibres
containing SSD help in the burn-wound healing study on Male Sprague Dawley (SD) rats. The healing effect on
rats was examined by western blot analysis, digital camera observation, and histological analyses.
Conclusion: Burn is also considered the most grievous form of trauma. Nowadays, several large and foambased
formulations are used in wound healing, which heals the wound better than previously existing formulations
and is less prone to secondary infection. Recently, nanofiber delivery systems have piqued the interest of
academics as well as researchers because of its unique advantages and features, which include an extraordinarily
high surface to volume ratio, a highly porous structure, and tiny pore size.