Title:The Role of Heat Shock Protein 40 in Carcinogenesis and Biology of Colorectal
Cancer
Volume: 28
Issue: 18
Author(s): Fereshteh Asgharzadeh, Reyhaneh Moradi-Marjaneh*Mahdi Moradi Marjaneh*
Affiliation:
- Department of Physiology,
School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
- Department of
Infectious Disease, Faculty of Medicine, Imperial College London, London, United Kingdom
Keywords:
Heat shock protein 40, chaperone DnaJ, colorectal cancer, carcinogenesis, metastasis, treatment.
Abstract: Colorectal cancer (CRC) is the third most common cancer worldwide. Despite the enormous amount
of effort in the diagnosis and treatment of CRC, the overall survival rate of patients remains low. The precise
molecular and cellular basis underlying CRC has not been completely understood yet. Over time, new genes
and molecular pathways involved in the pathogenesis of the disease are being identified. The accurate discovery
of these genes and signaling pathways are important and urgent missions for the next generation of anticancer
therapy research. Chaperone DnaJ, also known as Hsp40 (heat shock protein 40), has been of particular interest
in CRC pathogenesis, as it is involved in the fundamental cell activities for maintaining cellular homeostasis.
Evidence shows that protein family members of DnaJ/Hsp40 play both roles, enhancing and reducing the
growth of CRC cells. In the present review, we focus on the current knowledge of the molecular mechanisms
responsible for DnaJ/Hsp40 in CRC carcinogenesis and biology.
