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Research Article

Syzygium jambolanum Homeopathic Formulation Improves Diabetes Modulating Adipogenic Genes in Diet-Induced Obese Mice: Comparison to the Standard Metformin Treatment

Author(s): Daniele Cristina Moreira, Victor Hugo Dantas Guimarães, Alfredo Mauricio Batista de Paula, André Luiz Sena Guimarães, Luiz Fernando de Rezende, Carlos Eduardo Mendes D’Angelis, Francine Souza Alves da Fonseca and Sérgio Henrique Sousa Santos*

Volume 8, Issue 6, 2022

Published on: 01 August, 2022

Article ID: e120522204677 Pages: 11

DOI: 10.2174/2215083808666220512150214

Price: $65

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Abstract

Background: Homeopathy is an alternative therapy that uses substance dilution. The homeopathic preparation of Syzygium jambolanum (SJ) has a potential use in the treatment of glycemic disorders.

Objective: In this context, the aim of the present study was to evaluate the use of the SJ homeopathic preparation on treating obesity and glycemic/metabolic disorders compared with metformin treatment (diabetes gold-treatment) in a mice model fed a high-fat diet.

Methods: A total of 48 Swiss male mice were divided into six groups with eight animals each, randomly distributed as follows: obese and non-obese groups, treated and non treated with SJ or metformin. Obesity was induced by high-lard/high-sugar diet, while the control mice (ST) received a standard diet for 12 weeks, after which, for 30 days, the animals received a preparation of 20 μl/100g/body-weight of SJ or a dose of 250 mg/kg metformin (by gavage). The control groups ST and HLHS received water gavage. Body composition and biochemical parameters were evaluated. The adipose genes for lipogenesis and thermogenesis were tested.

Results: The mice treated with Syzygium jambolanum presented reduced weight gain (p< 0.02) and smaller adipose tissue weight, average difference compared to the mice treated with metformin, and both groups showed improved insulin sensitivity (p<0.04). The main results were associated with the modulation of the adipogenesis pathway (C/EPBα and PPARγ) and the thermogenic gene Uncoupling Protein 1 (UCP1).

Conclusion: Syzygium jambolanum homeopathic preparation leads to lower body weight, blood glucose and total cholesterol with higher high-density lipoprotein (HDL), pointing to its efficiency in treating diabetes and obesity.

Keywords: Diabetes mellitus, homeopathy, adipokine, cytokine, Syzygium jambolanum, glycemic disorders.

Graphical Abstract

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