Title:K2CO3/TBAB, a Composite of Inorganic and Organic Salts, a Novel and
Powerful Media for Regioselective Michael Addition of Dihydropyrimidinones
to Acrylic Esters Under and Without Solvent Conditions
Volume: 19
Issue: 12
Author(s): Sevil Bonabi, Gholamhassan Imanzadeh*, Roghayyeh Asgharzadeh and Zahra Soltanzadeh
Affiliation:
- Department of Chemistry, Faculty of Sciences, University of Mohaghegh Ardabili 56199-11367, Ardabil, Iran
Keywords:
Regioselective synthesis, dihydropyrimidinones, aza-Michael addition, acrylic esters, solvent conditions, organic salts.
Abstract:
Aims: Synthesis of dihydropyrimidinones derivatives.
Background: carrying out reactions in the green route and organic solvent-free conditions.
Objective: Regioselective Michael addition of dihydropyrimidinones to acrylic esters.
Methods: The reaction proceeded in the presence of K2CO3/TBAB, a media of inorganic base K2CO3
and organic ionic salt TBAB (tetrabutylammonium bromide) at 100°C.
Results: A series of new dihydropyrimidinone derivatives using aza-Michael addition reaction were
synthesized under solvent-free conditions.
Conclusion: The reaction is characterized by high efficiency, relatively short reaction time, high
yields, simple environmentally friendly reaction conditions.
Other: The reaction of acrylic esters with dihydropyrimidinones produced N3-substituted derivative of
dihydropyrimidinones with 85-95% yields in 6 h.