Title:ITGA9: Potential Biomarkers and Therapeutic Targets in Different Tumors
Volume: 28
Issue: 17
Author(s): Yinxin Wu, Jinlan Chen, Fangshun Tan, Bei Wang, Wen Xu and Chengfu Yuan*
Affiliation:
- Third-Grade Pharmacological Laboratory on Traditional Chinese Medicine, State Administration of Traditional Chinese Medicine,
China Three Gorges University, Yichang 443002, China
- Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University, Yichang 443002, China
- Medical College China Three Gorges University, Yichang 443002,
China
Keywords:
Integrin subunits, ITGA9, cancer, mechanisms, biomarkers, targets.
Abstract: Integrins are a class of cell surface adhesion molecules composed of α subunit (ITGA) and β subunit
(ITGB). They belong to heterodimer transmembrane glycoproteins. Their main function in organisms is as the
receptor of cell adhesion molecules (CAMs) and extracellular matrix (ECM). According to the current research
integration analysis, integrin α9 (ITGA9) is one of the integrin subunits, and there are few studies on ITGA9
among integrins. ITGA9 can improve cell migration and regulate various cellular biological functions, such as
tumor cell proliferation, adhesion, invasion, and angiogenesis. However, its abnormal expression mechanism in
cancer and its specific role in tumor growth and metastasis are still unknown to a great extent. This review
reveals the role of ITGA9 in the complex pathogenesis of many tumors and cancers, providing a new direction
for the treatment of tumors and cancers. Relevant studies were retrieved and collected through the PubMed system.
After determining ITGA9 as the research object, we found a close relationship between ITGA9 and tumorigenesis
by analyzing the research articles on ITGA9 in the PubMed system in the last 15 years and further
determined the references mainly based on the influencing factors of the articles. Thus, the role of ITGA9 in
tumor and cancer genesis, proliferation, and metastasis was reviewed and analyzed. ITGA9 is an integrin subunit,
which has been proved to be abnormally expressed in many tumors. After sorting and analyzing the
research data, it was found that the abnormal expression of ITGA9 in a variety of tumors, including glioblastoma,
rhabdomyosarcoma, melanoma, hepatocellular carcinoma, nasopharyngeal carcinoma, multiple myeloma,
non-small cell lung cancer, and prostate cancer, was closely related to the proliferation, metastasis, adhesion,
and angiogenesis of tumor cells. These results suggest that ITGA9 plays an important role in the occurrence and
development of tumors. The integrin subunit ITGA9 may serve as a biomarker for the diagnosis of tumors and a
potential therapeutic target for anti-tumor therapies.
