Title:Diammonium Glycyrrhizinate Preparation for Liver Function Recovery in Chronic
Hepatitis B in China: A Meta-analysis with Trial Sequential Analysis
Volume: 28
Issue: 25
Author(s): Yibo Liu, Wenfang Guo and Minhui Li*
Affiliation:
- College of Traditional Chinese Medicine, Institute Mongolia Medical University, Hohhot (010020), China
- Department of Drug
Laboratory, Inner Mongolia Institute of Traditional Chinese Medicine, Hohhot (010020), China
- Department of Drug Laboratory, Inner Mongolia Autonomous
Region Hospital of Traditional Chinese Medicine, Hohhot (010020), China
- Baotou Medical College, Baotou (014060), China
Keywords:
Diammonium glycyrrhizinate, chronic hepatitis B, meta-analysis, TCM, TSA, ALT.
Abstract:
Background: The treatment of chronic hepatitis B (CHB) comprises a global medical problem, and
the first-line clinical drugs have obvious shortcomings. The use of the plant extract diammonium glycyrrhizinate
(DG) in food and medicine has gradually widened because of its safety and effectiveness. DG is mainly
used for liver-disease treatment in clinical practice, but DG intervention for CHB lacks systematic evidence.
Methods: The included randomized controlled trials were analyzed by comparator and control respectively for
alanine aminotransferase (ALT), aspartate transaminase (AST), total bilirubin (TBIL) levels, hepatitis B virus
DNA negative conversion ratio, and total effective rate, and subgroup analysis was conducted for intervention
time, intervention dosage form, comparator drug, and combination drug, among others. Trial sequential analysis
was used to verify the results.
Result: DG could effectively reduce ALT, AST, TBIL, and other liver-function indexes and had a definite effect
on liver-function recovery. From the beginning of the intervention to 3 months, the effect was significantly
better than that of conventional treatment. Compared with other drugs, different dosage forms had differences
in efficacy, and DG enteric-coated capsules and injections were lower than compound glycyrrhizin and magnesium
isoglycyrrhizin. Meanwhile, DG capsules had no significant difference from them. Meanwhile, trial sequential
analysis of the main results confirmed the reliability of the conclusion.
Conclusion: To our knowledge, this was the first relatively complete meta-analysis and systematic evaluation
of the efficacy of DG intervention for CHB; liver-function recovery was discussed in the context of traditional
Chinese medicine thinking, and DG’s therapeutic effect on CHB was defined.
