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Infectious Disorders - Drug Targets

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ISSN (Print): 1871-5265
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Recent Discoveries of Nitrogen-Containing Heterocyclic Compounds as InhA Inhibitors against Mycobacterium tuberculosis: An Overview

Author(s): Pratibha D. Gupta, Kalpana N. Tilekar, Neha M. Upadhyay and Ramaa C.S*

Volume 22, Issue 8, 2022

Published on: 18 August, 2022

Article ID: e200422203820 Pages: 11

DOI: 10.2174/1871526522666220420092618

Price: $65

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Abstract

It is a formidable challenge to treat tuberculosis as there are increasing cases of multidrugresistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) cases. Moreover, the emergence of totally drug-resistant tuberculosis (TDR-TB) makes it vital and imperative to develop a new generation of anti-tubercular drugs to have control over resistance. The nitrogencontaining heterocyclic class of compounds is being studied extensively to ascertain their anti-TB potentials. Nitrogen-containing compounds have a broad range of targets; wherein, InhA is the most important one. Hence, the primary focus of this review is to summarize the recent developments in the discovery of nitrogen-containing heterocyclic compounds as InhA inhibitors to combat tuberculosis.

Keywords: Tuberculosis, anti-tuberculosis agents, InhA inhibitors, isoniazid, triclosan, GEQ heterocycle.

Graphical Abstract

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