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Review Article

质谱分析在发现抗生素和细菌耐药机制中的作用:蛋白质组学和代谢组学方法

卷 30, 期 1, 2023

发表于: 13 May, 2022

页: [30 - 58] 页: 29

弟呕挨: 10.2174/0929867329666220329090822

价格: $65

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摘要

抗生素的滥用和不正确使用导致了耐药细菌的增殖。耐药细菌的出现已成为全球最大的健康问题之一，人们为此付出了巨大的努力。然而，尽管做出了这些努力，耐药菌株的出现正在迅速增加，而新型抗生素的发现却落后了。因此，更详细地了解细菌耐药机制和具有抗菌作用的物质的作用机制，以确定生物标志物、治疗靶点和开发新的抗生素是至关重要的。代谢组学和蛋白质组学结合质谱技术进行数据采集是合适的技术，并已成功应用。本文综述了代谢组学和蛋白质组学方法的基本方面及其在细菌耐药机制研究中的应用。

关键词: 质谱，蛋白质组学，代谢组学，抗生素，细菌耐药性，增殖

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