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Review Article

药用和膳食植物中的植物化合物:预防和治疗宫颈癌的多靶点制剂

卷 29, 期 26, 2022

发表于: 05 April, 2022

页: [4481 - 4506] 页: 26

弟呕挨: 10.2174/0929867329666220301114251

价格: $65

Open Access Journals Promotions 2
摘要

宫颈癌是全世界妇女癌症死亡的第四大原因。由于宫颈癌的高发病率和高死亡率，对有效的诊断、治疗和预防制剂的需求尚未得到满足。目前，晚期转移性宫颈癌的首选治疗策略包括手术、放疗和化疗。然而，宫颈癌对化疗逐渐产生耐药性，从而降低其疗效。在过去的几十年里，植物化学物质，即从植物中产生的化合物的总称，因其在预防宫颈癌方面的作用而受到关注。这种在预防子宫颈癌中的作用已经引起了人们对水果和蔬菜的药用特性的关注。目前正在评估植物化学物质阻断参与宫颈癌发生的蛋白质和对宫颈癌的化学耐药性的能力。对顺铂、阿霉素和5-氟尿嘧啶等癌症药物的耐药已成为药物化疗的一个重要限制。然而，顺铂与其他植物化学物质的联合已被认为是抑制顺铂耐药性的一种有希望的替代方法。由于植物化学物质具有抗氧化、抗炎和抗增殖的潜能，对包括宫颈癌在内的许多癌症具有很好的化学预防和化疗作用。此外，这种植物化学物质通过上下调节各种蛋白质来调节细胞信号通路的能力已被认为具有治疗潜力。在宫颈癌细胞中，植物化学物质还具有广泛的生物学功能，包括细胞周期阻滞、诱导凋亡、抑制侵袭和迁移等。大量研究揭示了不同信号蛋白及其信号通路在宫颈癌发病机制中的重要作用。在此，我们综述了几种膳食植物化学物质通过调节各种分子靶点来改变致癌作用的能力。

关键词: 宫颈癌，癌变，氧化应激，化学抗性，植物化学物质，细胞毒性，化疗，凋亡。

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