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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Research Article

Synthesis of Pyrimidine Hybrids Based on 4H-Pyran and 4H-Chromene Privileged Structures

Author(s): Adeleh Moshtaghi Zonouz*, Parisa Ghaffari, and Azita Pourreza

Volume 19, Issue 11, 2022

Published on: 24 March, 2022

Page: [993 - 998] Pages: 6

DOI: 10.2174/1570178619666220209154646

Price: $65

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Abstract

A combinatorial library of pyrimidine hybrids based on 4H-chromene and 4H-pyran privileged structures has been developed by reacting phenyl isothiocyanate with chromene derivatives 1a-j and pyranopyrazoles 2a-f in refluxing dry pyridine, respectively. Thus, the target pyrimidine hybrids 3a-j and 4a-f were obtained in good yields with a simple reaction strategy.

Keywords: Privileged structures, 4H-pyrans, chromene, pyrimidine hybrids, medicinal chemistry, 4H-chromene.

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