Title:COVID-19 Infection in Pregnancy: A Review
Volume: 22
Issue: 5
Author(s): Sabrina Jahan Mily, Kazi Mahmuda Akter, Nowshin Jabin, Saikat Mitra, Talha Bin Emran, Monisha Nandi, Sumit Kumar Baral, Md. Zia Uddin, Jewel Mallick, Arkajyoti Paul, Syed Uzair Ali Shah, Abdur Rauf, Ishaq N. Khan and Mohammad S. Mubarak*
Affiliation:
- Department of Chemistry, The University of Jordan, Amman 11942, Jordan
Keywords:
COVID-19, coronavirus, pandemic, pregnancy, management, infection.
Abstract: Coronavirus disease 2019 (COVID-19), which is a highly contagious viral illness caused by
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has had a catastrophic effect on
the world's demographics, resulting in more than 3.8 million deaths worldwide and establishing itself as
the most serious global health crisis since the 1918 influenza pandemic. Several questions remain unanswered
regarding the effects of COVID-19 disease during pregnancy. Although most infections are mild
in high-risk populations, the severe disease frequently leads to intubation, intensive care unit admission,
and, in some cases, death. Hormonal and physiological changes in the immune and respiratory systems,
cardiovascular function, and coagulation may affect the progression of COVID-19 disease in pregnancy.
However, the consequences of coronavirus infection on implantation, fetal growth and development,
labor, and newborn health have yet to be determined, and, consequently, a coordinated global effort is
needed in this respect. Principles of management concerning COVID-19 in pregnancy include early
isolation, aggressive infection control procedures, oxygen therapy, avoidance of fluid overload, consideration
of empiric antibiotics (secondary to bacterial infection risk), laboratory testing for the virus and
co-infection, fetal and uterine contraction monitoring, prevention, and / or treatment of thromboembolism
early mechanical ventilation for progressive respiratory failure, individualized delivery planning,
and a team-based approach with multispecialty consultations. This review focuses on COVID-19 during
pregnancy, its management, and the area where further investigations are needed to reduce the risk to
mothers and their newborns.
