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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Online): 2212-3873

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Review Article

Increasing Risk Factors for Non-Alcoholic Fatty Liver Disease; an Insight into Chronic Periodontitis and Insulin Resistance

Author(s): Sreenu Thalla*, Kamaraj R. and Kavitha A.

Volume 22, Issue 8, 2022

Published on: 18 April, 2022

Page: [807 - 814] Pages: 8

DOI: 10.2174/1871530322666220104095534

Price: $65

Abstract

Non-alcoholic fatty liver disease (NAFLD) is marked by the excessive intrusion of triglycerides into hepatocytes without any role of alcohol consumption. Various risk factors have been attributed to this disease pathogenesis, including metabolic disorders, immune response, and even an intricate relationship between the two. The role of insulin resistance (IR) in NAFLD has long been known; however, the molecular basis of disease progression under this metabolic backdrop is still being investigated. Similarly, the periodontitis-mediated immune response is another major factor involved in NAFLD manifestation, which has generated huge interest. The prevalence of pathogenic bacteria elicits a strong immune response, which according to the studies shows a strong correlation with NAFLD state. Such pre-existing conditions have a strong probability of explaining the disease onset. Additionally, increasing reports on inflammatory response and its links to insulin resistance have further increased the scope of understanding NAFLD. Through this review, we aim to elaborate on these factors explaining their role in the disease progression.

Keywords: Non-alcoholic fatty liver disease, chronic periodontitis, insulin resistance, inflammatory response, hepatic steatosis, cardio vascular disease.

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[1]
Younossi, Z.M. Non-alcoholic fatty liver disease - A global public health perspective. J. Hepatol., 2019, 70(3), 531-544.
[http://dx.doi.org/10.1016/j.jhep.2018.10.033] [PMID: 30414863]
[2]
Younossi, Z.; Anstee, Q.M.; Marietti, M.; Hardy, T.; Henry, L.; Eslam, M.; George, J.; Bugianesi, E. Global burden of NAFLD and NASH: Trends, predictions, risk factors and prevention. Nat. Rev. Gastroenterol. Hepatol., 2018, 15(1), 11-20.
[http://dx.doi.org/10.1038/nrgastro.2017.109] [PMID: 28930295]
[3]
Araújo, A.R.; Rosso, N.; Bedogni, G.; Tiribelli, C.; Bellentani, S. Global epidemiology of non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: What we need in the future. Liver Int., 2018, 38(Suppl. 1), 47-51.
[http://dx.doi.org/10.1111/liv.13643] [PMID: 29427488]
[4]
Maurice, J.; Manousou, P. Non-alcoholic fatty liver disease. Clin. Med. (Lond.), 2018, 18(3), 245-250.
[http://dx.doi.org/10.7861/clinmedicine.18-3-245] [PMID: 29858436]
[5]
Byrne, C.D.; Targher, G. NAFLD: A multisystem disease. J. Hepatol., 2015, 62(1), S47-S64.
[http://dx.doi.org/10.1016/j.jhep.2014.12.012] [PMID: 25920090]
[6]
Wree, A.; Broderick, L.; Canbay, A.; Hoffman, H.M.; Feldstein, A.E. From NAFLD to NASH to cirrhosis-new insights into disease mechanisms. Nat. Rev. Gastroenterol. Hepatol., 2013, 10(11), 627-636.
[http://dx.doi.org/10.1038/nrgastro.2013.149] [PMID: 23958599]
[7]
Angulo, P. Nonalcoholic fatty liver disease. N. Engl. J. Med., 2002, 346(16), 1221-1231.
[http://dx.doi.org/10.1056/NEJMra011775] [PMID: 11961152]
[8]
Neuschwander-Tetri, B.A.; Caldwell, S.H. Nonalcoholic steatohepatitis: summary of an AASLD single topic conference. Hepatology, 2003, 37(5), 1202-1219.
[http://dx.doi.org/10.1053/jhep.2003.50193] [PMID: 12717402]
[9]
Tilg, H.; Moschen, A.R. Evolution of inflammation in nonalcoholic fatty liver disease: The multiple parallel hits hypothesis. Hepatology, 2010, 52(5), 1836-1846.
[http://dx.doi.org/10.1002/hep.24001] [PMID: 21038418]
[10]
Nagarajan, R.; Miller, C.S.; Dawson, D., III; Ebersole, J.L. Biologic modelling of periodontal disease progression. J. Clin. Periodontol., 2019, 46(2), 160-169.
[http://dx.doi.org/10.1111/jcpe.13064] [PMID: 30629741]
[11]
Pan, W.; Wang, Q.; Chen, Q. The cytokine network involved in the host immune response to periodontitis. Int. J. Oral Sci., 2019, 11(3), 30.
[http://dx.doi.org/10.1038/s41368-019-0064-z] [PMID: 31685798]
[12]
Hegde, R.; Awan, K.H. Effects of periodontal disease on systemic health. Dis. Mon., 2019, 65(6), 185-192.
[http://dx.doi.org/10.1016/j.disamonth.2018.09.011] [PMID: 30384973]
[13]
Hashim, N.T. Oral microbiology in periodontal health and disease. In: Oral Microbiology in Periodontitis; InTech, 2018.
[http://dx.doi.org/10.5772/intechopen.75709]
[14]
Curtis, M.A.; Diaz, P.I.; Van Dyke, T.E. The role of the microbiota in periodontal disease. Periodontol. 2000, 2020, 83(1), 14-25.
[http://dx.doi.org/10.1111/prd.12296] [PMID: 32385883]
[15]
Socransky, S.S.; Haffajee, A.D.; Cugini, M.A.; Smith, C.; Kent, R.L., Jr Microbial complexes in subgingival plaque. J. Clin. Periodontol., 1998, 25(2), 134-144.
[http://dx.doi.org/10.1111/j.1600-051X.1998.tb02419.x] [PMID: 9495612]
[16]
Gross, E.L.; Beall, C.J.; Kutsch, S.R.; Firestone, N.D.; Leys, E.J.; Griffen, A.L. Beyond Streptococcus mutans: Dental caries onset linked to multiple species by 16S rRNA community analysis. PLoS One, 2012, 7(10), e47722.
[http://dx.doi.org/10.1371/journal.pone.0047722] [PMID: 23091642]
[17]
Silva, N.; Abusleme, L.; Bravo, D.; Dutzan, N.; Garcia-Sesnich, J.; Vernal, R.; Hernández, M.; Gamonal, J. Host response mechanisms in periodontal diseases. J. Appl. Oral Sci., 2015, 23(3), 329-355.
[http://dx.doi.org/10.1590/1678-775720140259] [PMID: 26221929]
[18]
Kornman, K.S. Mapping the pathogenesis of periodontitis: A new look. J. Periodontol., 2008, 79(8)(Suppl.), 1560-1568.
[http://dx.doi.org/10.1902/jop.2008.080213] [PMID: 18673011]
[19]
Wang, Y.; Andrukhov, O.; Rausch-Fan, X. Oxidative stress and antioxidant system in periodontitis. Front. Physiol., 2017, 8, 910.
[http://dx.doi.org/10.3389/fphys.2017.00910] [PMID: 29180965]
[20]
Szkaradkiewicz, A.K.; Karpiński, T.M. Microbiology of chronic periodontitis. J. Biol. Earth Sci., 2013, 3, M14-M20.
[21]
Hirsch, S. Periodontal diseases. Cah Odontostomatol Touraine, 1971, 3(3), 13-36.
[PMID: 5287842]
[22]
Graves, D.T.; Corrêa, J.D.; Silva, T.A. The oral microbiota is modified by systemic diseases. J. Dent. Res., 2019, 98(2), 148-156.
[http://dx.doi.org/10.1177/0022034518805739] [PMID: 30359170]
[23]
Quirynen, M.; De Soete, M.; Dierickx, K.; van Steenberghe, D. The intra-oral translocation of periodontopathogens jeopardises the outcome of periodontal therapy. A review of the literature. J. Clin. Periodontol., 2001, 28(6), 499-507.
[http://dx.doi.org/10.1034/j.1600-051x.2001.028006499.x] [PMID: 11350516]
[24]
Akira, S.; Takeda, K.; Kaisho, T. Toll-like receptors: Critical proteins linking innate and acquired immunity. Nat. Immunol., 2001, 2(8), 675-680.
[http://dx.doi.org/10.1038/90609] [PMID: 11477402]
[25]
Gamonal, J.; Sanz, M.; O’Connor, A.; Acevedo, A.; Suarez, I.; Sanz, A.; Martínez, B.; Silva, A. Delayed neutrophil apoptosis in chronic periodontitis patients. J. Clin. Periodontol., 2003, 30(7), 616-623.
[http://dx.doi.org/10.1034/j.1600-051X.2003.00350.x] [PMID: 12834499]
[26]
Fujita, M.; Kuraji, R.; Ito, H.; Hashimoto, S.; Toen, T.; Fukada, T.; Numabe, Y. Histological effects and pharmacokinetics of lipopolysaccharide derived from Porphyromonas gingivalis on rat maxilla and liver concerning with progression into non-alcoholic steatohepatitis. J. Periodontol., 2018, 89(9), 1101-1111.
[http://dx.doi.org/10.1002/JPER.17-0678] [PMID: 29799627]
[27]
Furusho, H.; Miyauchi, M.; Hyogo, H.; Inubushi, T.; Ao, M.; Ouhara, K.; Hisatune, J.; Kurihara, H.; Sugai, M.; Hayes, C.N.; Nakahara, T.; Aikata, H.; Takahashi, S.; Chayama, K.; Takata, T. Dental infection of Porphyromonas gingivalis exacerbates high fat diet-induced steatohepatitis in mice. J. Gastroenterol., 2013, 48(11), 1259-1270.
[http://dx.doi.org/10.1007/s00535-012-0738-1] [PMID: 23307045]
[28]
Al-Dayyat, H.M.; Rayyan, Y.M.; Tayyem, R.F. Non-alcoholic fatty liver disease and associated dietary and lifestyle risk factors. Diabetes Metab. Syndr., 2018, 12(4), 569-575.
[http://dx.doi.org/10.1016/j.dsx.2018.03.016] [PMID: 29571977]
[29]
Fan, J-G.; Zhu, J.; Li, X-J.; Chen, L.; Lu, Y-S.; Li, L.; Dai, F.; Li, F.; Chen, S-Y. Fatty liver and the metabolic syndrome among Shanghai adults. J. Gastroenterol. Hepatol., 2005, 20(12), 1825-1832.
[http://dx.doi.org/10.1111/j.1440-1746.2005.04058.x] [PMID: 16336439]
[30]
Flegal, K.M.; Carroll, M.D.; Ogden, C.L.; Johnson, C.L. Prevalence and trends in obesity among US adults, 1999-2000. JAMA, 2002, 288(14), 1723-1727.
[http://dx.doi.org/10.1001/jama.288.14.1723] [PMID: 12365955]
[31]
Khan, R.S.; Bril, F.; Cusi, K.; Newsome, P.N. Modulation of insulin resistance in nonalcoholic fatty liver disease. Hepatology, 2019, 70(2), 711-724.
[http://dx.doi.org/10.1002/hep.30429] [PMID: 30556145]
[32]
Hotamisligil, G.S.; Shargill, N.S.; Spiegelman, B.M. Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science, 1993, 259(5091), 87-91.
[http://dx.doi.org/10.1126/science.7678183] [PMID: 7678183]
[33]
Petersen, M.C.; Madiraju, A.K.; Gassaway, B.M.; Marcel, M.; Nasiri, A.R.; Butrico, G.; Marcucci, M.J.; Zhang, D.; Abulizi, A.; Zhang, X.M.; Philbrick, W. Insulin receptor thr 1160 phosphorylation mediates lipid-induced hepatic insulin resistance. J. Clin. Invest., 2016, 126, 4361-4371.
[34]
Benhamed, F.; Denechaud, P-D.; Lemoine, M.; Robichon, C.; Moldes, M.; Bertrand-Michel, J.; Ratziu, V.; Serfaty, L.; Housset, C.; Capeau, J.; Girard, J.; Guillou, H.; Postic, C. The lipogenic transcription factor ChREBP dissociates hepatic steatosis from insulin resistance in mice and humans. J. Clin. Invest., 2012, 122(6), 2176-2194.
[http://dx.doi.org/10.1172/JCI41636] [PMID: 22546860]
[35]
Song, I-S.; Han, K.; Park, Y-M.; Ji, S.; Jun, S.H.; Ryu, J-J.; Park, J-B. Severe periodontitis is associated with insulin resistance in non-abdominal obese adults. J. Clin. Endocrinol. Metab., 2016, 101(11), 4251-4259.
[http://dx.doi.org/10.1210/jc.2016-2061] [PMID: 27598510]
[36]
Pulido-Moran, M.; Bullon, P.; Morillo, J.M.; Battino, M.; Quiles, J.L.; Ramirez-Tortosa, M. The relationship between insulin resistance and periodontitis is not affected by Mediterranean diet in a Spanish population. Arch. Oral Biol., 2017, 77, 62-67.
[http://dx.doi.org/10.1016/j.archoralbio.2017.01.023] [PMID: 28178586]
[37]
Moritz, A.; Mealey, B. Periodontal disease, insulin resistance, and diabetes mellitus: A review and clinical implications. Grand Rounds Oral-Sys Med, 2006, 2, 13-20.
[38]
Akinkugbe, A.A.; Avery, C.L.; Barritt, A.S.; Cole, S.R.; Lerch, M.; Mayerle, J.; Offenbacher, S.; Petersmann, A.; Nauck, M.; Völzke, H.; Slade, G.D.; Heiss, G.; Kocher, T.; Holtfreter, B. Do genetic markers of inflammation modify the relationship between periodontitis and nonalcoholic fatty liver disease? findings from the SHIP study. J. Dent. Res., 2017, 96(12), 1392-1399.
[http://dx.doi.org/10.1177/0022034517720924] [PMID: 28732187]
[39]
Alazawi, W.; Bernabe, E.; Tai, D.; Janicki, T.; Kemos, P.; Samsuddin, S.; Syn, W-K.; Gillam, D.; Turner, W. Periodontitis is associated with significant hepatic fibrosis in patients with non-alcoholic fatty liver disease. PLoS One, 2017, 12(12), e0185902.
[http://dx.doi.org/10.1371/journal.pone.0185902] [PMID: 29220367]
[40]
Akinkugbe, A.A.; Slade, G.D.; Barritt, A.S.; Cole, S.R.; Offenbacher, S.; Petersmann, A.; Kocher, T.; Lerch, M.M.; Mayerle, J.; Völzke, H.; Heiss, G.; Holtfreter, B. Periodontitis and non-alcoholic fatty liver disease, a population-based cohort investigation in the study of health in Pomerania. J. Clin. Periodontol., 2017, 44(11), 1077-1087.
[http://dx.doi.org/10.1111/jcpe.12800] [PMID: 28804947]
[41]
Kamata, Y.; Kessoku, T.; Shimizu, T.; Kobayashi, T.; Kurihashi, T.; Sato, S.; Kuraji, S.; Aoyama, N.; Iwasaki, T.; Takashiba, S.; Hamada, N.; Kodama, T.; Tamura, T.; Ino, S.; Higurashi, T.; Taguri, M.; Yamanaka, T.; Yoneda, M.; Usuda, H.; Wada, K.; Nakajima, A.; Minabe, M. Efficacy and safety of PERIOdontal treatment versus usual care for Nonalcoholic liver disease: Protocol of the PERION multicenter, two-arm, open-label, randomized trial. Trials, 2020, 21(1), 291.
[http://dx.doi.org/10.1186/s13063-020-4201-y] [PMID: 32293522]
[42]
Hassan, S.A. Periodontitis and liver disease a relation - Review. IP journal of urology. Nephrol. Hepatol. Sci., 2020, 2(4), 53-56.
[43]
Hadizadeh, F.; Faghihimani, E.; Adibi, P. Nonalcoholic fatty liver disease: Diagnostic biomarkers. World J. Gastrointest. Pathophysiol., 2017, 8(2), 11-26.
[http://dx.doi.org/10.4291/wjgp.v8.i2.11] [PMID: 28573064]
[44]
Wiener, R.C.; Sambamoorthi, U.; Jurevic, R.J. Association of alanine aminotransferase and periodontitis: A Cross-sectional analysis-NHANES 2009-2012. Int. J. Inflamm., 2016, 2016, 3901402.
[http://dx.doi.org/10.1155/2016/3901402] [PMID: 26981311]
[45]
Eke, P.I.; Page, R.C.; Wei, L.; Thornton-Evans, G.; Genco, R.J. Update of the case definitions for population-based surveillance of periodontitis. J. Periodontol., 2012, 83(12), 1449-1454.
[http://dx.doi.org/10.1902/jop.2012.110664] [PMID: 22420873]
[46]
Shin, H.S. Association between periodontal status and non-alcoholic fatty liver disease in a Korean adult population: A nationwide cross-sectional study. J. Periodontol., 2020, 91(4), 524-532.
[http://dx.doi.org/10.1002/JPER.19-0291] [PMID: 31484207]
[47]
Kim, J.Y.; Lee, G.N.; Song, H.C.; Park, Y.M.; Ahn, Y.B.; Han, K.; Ko, S.H. Association between fatty liver index and periodontitis: the Korea national health and nutrition examination survey. Sci. Rep., 2020, 10(1), 3805.
[http://dx.doi.org/10.1038/s41598-020-60797-7] [PMID: 32123238]
[48]
Iwasaki, T.; Hirose, A.; Azuma, T.; Ohashi, T.; Watanabe, K.; Obora, A.; Deguchi, F.; Kojima, T.; Isozaki, A.; Tomofuji, T. Correlation between ultrasound-diagnosed non-alcoholic fatty liver and periodontal condition in a cross-sectional study in Japan. Sci. Rep., 2018, 8(1), 7496.
[http://dx.doi.org/10.1038/s41598-018-25857-z] [PMID: 29760403]
[49]
Morita, T.; Yamazaki, Y.; Fujiharu, C.; Ishii, T.; Seto, M.; Nishinoue, N.; Sasaki, Y.; Kawato, T.; Motohashi, M.; Maeno, M. Serum γ-glutamyltransferase level is associated with periodontal disease independent of drinking habits in Japanese adults. Med. Sci. Monit., 2014, 20, 2109-2116.
[http://dx.doi.org/10.12659/MSM.891204] [PMID: 25360830]
[50]
Hatasa, M.; Yoshida, S.; Takahashi, H.; Tanaka, K.; Kubotsu, Y.; Ohsugi, Y.; Katagiri, T.; Iwata, T.; Katagiri, S. Relationship between NAFLD and periodontal disease from the view of clinical and basic research, and immunological response. Int. J. Mol. Sci., 2021, 22(7), 3728.
[http://dx.doi.org/10.3390/ijms22073728] [PMID: 33918456]
[51]
Furuta, M.; Ekuni, D.; Yamamoto, T.; Irie, K.; Koyama, R.; Sanbe, T.; Yamanaka, R.; Morita, M.; Kuroki, K.; Tobe, K. Relationship between periodontitis and hepatic abnormalities in young adults. Acta Odontol. Scand., 2010, 68(1), 27-33.
[http://dx.doi.org/10.3109/00016350903291913] [PMID: 19878045]
[52]
Nakahara, T.; Hyogo, H.; Ono, A.; Nagaoki, Y.; Kawaoka, T.; Miki, D.; Tsuge, M.; Hiraga, N.; Hayes, C.N.; Hiramatsu, A.; Imamura, M.; Kawakami, Y.; Aikata, H.; Ochi, H.; Abe-Chayama, H.; Furusho, H.; Shintani, T.; Kurihara, H.; Miyauchi, M.; Takata, T.; Arihiro, K.; Chayama, K. Involvement of Porphyromonas gingivalis in the progression of non-alcoholic fatty liver disease. J. Gastroenterol., 2018, 53(2), 269-280.
[http://dx.doi.org/10.1007/s00535-017-1368-4] [PMID: 28741270]
[53]
Yoneda, M.; Naka, S.; Nakano, K.; Wada, K.; Endo, H.; Mawatari, H.; Imajo, K.; Nomura, R.; Hokamura, K.; Ono, M.; Murata, S.; Tohnai, I.; Sumida, Y.; Shima, T.; Kuboniwa, M.; Umemura, K.; Kamisaki, Y.; Amano, A.; Okanoue, T.; Ooshima, T.; Nakajima, A. Involvement of a periodontal pathogen, Porphyromonas gingivalis on the pathogenesis of non-alcoholic fatty liver disease. BMC Gastroenterol., 2012, 12, 16.
[http://dx.doi.org/10.1186/1471-230X-12-16] [PMID: 22340817]
[54]
Akinkugbe, A.A.; Barritt, A.S.; Cai, J.; Offenbacher, S.; Thyagarajan, B.; Khambaty, T.; Singer, R.; Kallwitz, E.; Heiss, G.; Slade, G.D. Periodontitis and prevalence of elevated aminotransferases in the Hispanic Community Health Study/Study of Latinos. J. Periodontol., 2018, 89(8), 949-958.
[http://dx.doi.org/10.1002/JPER.17-0579] [PMID: 29717494]
[55]
Arimatsu, K.; Yamada, H.; Miyazawa, H.; Minagawa, T.; Nakajima, M.; Ryder, M.I.; Gotoh, K.; Motooka, D.; Nakamura, S.; Iida, T.; Yamazaki, K. Oral pathobiont induces systemic inflammation and metabolic changes associated with alteration of gut microbiota. Sci. Rep., 2014, 4, 4828.
[http://dx.doi.org/10.1038/srep04828] [PMID: 24797416]
[56]
Demmer, R.T.; Breskin, A.; Rosenbaum, M.; Zuk, A.; LeDuc, C.; Leibel, R.; Paster, B.; Desvarieux, M.; Jacobs, D.R., Jr; Papapanou, P.N. The subgingival microbiome, systemic inflammation and insulin resistance: The oral infections, glucose intolerance and insulin resistance study. J. Clin. Periodontol., 2017, 44(3), 255-265.
[http://dx.doi.org/10.1111/jcpe.12664] [PMID: 27978598]
[57]
Hoozemans, J.; de Brauw, M.; Nieuwdorp, M.; Gerdes, V. Gut microbiome and metabolites in patients with NAFLD and after bariatric surgery: a comprehensive review. Metabolites, 2021, 11(6), 353.
[http://dx.doi.org/10.3390/metabo11060353] [PMID: 34072995]
[58]
Aron-Wisnewsky, J.; Vigliotti, C.; Witjes, J.; Le, P.; Holleboom, A.G.; Verheij, J.; Nieuwdorp, M.; Clément, K. Gut microbiota and human NAFLD: Disentangling microbial signatures from metabolic disorders. Nat. Rev. Gastroenterol. Hepatol., 2020, 17(5), 279-297.
[http://dx.doi.org/10.1038/s41575-020-0269-9] [PMID: 32152478]
[59]
Kuraji, R.; Ito, H.; Fujita, M.; Ishiguro, H.; Hashimoto, S.; Numabe, Y. Porphyromonas gingivalis induced periodontitis exacerbates progression of non-alcoholic steatohepatitis in rats. Clin. Exp. Dent. Res., 2016, 2(3), 216-225.
[http://dx.doi.org/10.1002/cre2.41] [PMID: 29744170]
[60]
Pessoa, L.S.; Pereira-da Silva, F.R.; Alves, E.H.; França, L.F.; di Lenardo, D.; Carvalho, J.S.; Martins, V.B.; Sousa, F.B.; Drumond, K.O.; Medeiros, J.V.; de Oliveira, J.S.; Vasconcelos, D.F. One or two ligatures inducing periodontitis are sufficient to cause fatty liver. Med. Oral Patol. Oral Cir. Bucal, 2018, 23(3), e269-e276.
[http://dx.doi.org/10.4317/medoral.22204] [PMID: 29680842]
[61]
Caussy, C.; Tripathi, A.; Humphrey, G.; Bassirian, S.; Singh, S.; Faulkner, C.; Bettencourt, R.; Rizo, E.; Richards, L.; Xu, Z.Z.; Downes, M.R.; Evans, R.M.; Brenner, D.A.; Sirlin, C.B.; Knight, R.; Loomba, R. A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease. Nat. Commun., 2019, 10(1), 1406.
[http://dx.doi.org/10.1038/s41467-019-09455-9] [PMID: 30926798]
[62]
Li, L.; Bao, J.; Chang, Y.; Wang, M.; Chen, B.; Yan, F. Gut microbiota may mediate the influence of periodontitis on prediabetes. J. Dent. Res., 2021, 100(12), 1387-1396.
[http://dx.doi.org/10.1177/00220345211009449] [PMID: 33899584]
[63]
Sasaki, N.; Katagiri, S.; Komazaki, R.; Watanabe, K.; Maekawa, S.; Shiba, T.; Udagawa, S.; Takeuchi, Y.; Ohtsu, A.; Kohda, T.; Tohara, H.; Miyasaka, N.; Hirota, T.; Tamari, M.; Izumi, Y. Endotoxemia by Porphyromonas gingivalis injection aggravates non-alcoholic fatty liver disease, disrupts glucose/lipid metabolism, and alters gut microbiota in mice. Front. Microbiol., 2018, 9, 2470.
[http://dx.doi.org/10.3389/fmicb.2018.02470] [PMID: 30405551]
[64]
Hamamoto, Y.; Ouhara, K.; Munenaga, S.; Shoji, M.; Ozawa, T.; Hisatsune, J.; Kado, I.; Kajiya, M.; Matsuda, S.; Kawai, T.; Mizuno, N.; Fujita, T.; Hirata, S.; Tanimoto, K.; Nakayama, K.; Kishi, H.; Sugiyama, E.; Kurihara, H. Effect of Porphyromonas gingivalis infection on gut dysbiosis and resultant arthritis exacerbation in mouse model. Arthritis Res. Ther., 2020, 22(1), 249.
[http://dx.doi.org/10.1186/s13075-020-02348-z] [PMID: 33076980]
[65]
Kashiwagi, Y.; Aburaya, S.; Sugiyama, N. Porphyromonas gingivalis induces entero-hepatic metabolic derangements with alteration of gut microbiota in a type 2 diabetes mouse model. Sci. Rep., 2021, 11(1), 18398.
[http://dx.doi.org/10.21203/rs.3.rs-279204/v1]
[66]
Kato, T.; Yamazaki, K.; Nakajima, M.; Date, Y.; Kikuchi, J.; Hase, K.; Ohno, H.; Yamazaki, K. Oral administration of Porphyromonas gingivalis alters the gut microbiome and serum metabolome. MSphere, 2018, 3(5), e00460-e18.
[http://dx.doi.org/10.1128/mSphere.00460-18] [PMID: 30333180]

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