摘要
溃疡性结肠炎(UC)是一种主要影响结肠和直肠的炎症性肠病(IBD)。它的主要特征包括黏膜炎症的复发和缓解,从直肠开始,典型地持续向近端延伸,通过部分或整个结肠。UC的发病取决于多种因素,如遗传易感性、上皮屏障缺陷、免疫反应失调和环境原因。最常见的症状是腹痛、体重减轻、粘液排出、带血腹泻、失禁、夜间排便、发烧和贫血。目前UC的治疗包括5-氨基水杨酸(5-ASA)及其衍生物、类固醇、免疫抑制剂和生物药物。然而,有限的疗效和不必要的副作用很难限制这些治疗策略。在过去的几十年里,研究已经推动了补充和替代药物治疗UC。各种营养药物在调节肠道炎症、改善症状方面表现出了良好的效果。体外研究证明,这些化合物具有广泛的积极健康作用,其特征是参与抗氧化防御、细胞增殖和基因表达。本综述分析了现有的关于不同类型的保健品及其作为IBD辅助治疗的潜在疗效的数据,特别是UC。
关键词: 溃疡性结肠炎、炎症性肠病、营养品、姜黄素、柚皮素、橄榄苦苷。
Current Medicinal Chemistry
Title:The Significant Role of Nutraceutical Compounds in Ulcerative Colitis Treatment
Volume: 29 Issue: 24
关键词: 溃疡性结肠炎、炎症性肠病、营养品、姜黄素、柚皮素、橄榄苦苷。
摘要: Ulcerative colitis (UC) is a type of inflammatory bowel disease (IBD) mainly affecting the colon and the rectum. Its main characteristics include relapsing and remitting mucosal inflammation, starting in the rectum and typically extending continuously proximally through part of or the entire colon. UC pathogenesis depends on multiple factors, such as genetic predisposition, defects in the epithelial barrier, dysregulated immune responses, and environmental causes. The most frequent symptoms are abdominal pain, weight loss, mucus discharge, bloody diarrhoea, incontinence, nocturnal defecations, fever, and anemia. Existing therapies for UC include 5-aminosalicylic acid (5-ASA) and its derivatives, steroids, immunosuppressants, and biological drugs. However, limited efficacy and unwanted adverse effects hardly limit these strategies of treatment. In the last decades, research studies have been driven towards complementary and alternative medicines for the treatment of UC. Various nutraceuticals have exhibited promising results in modulating intestinal inflammation while improving symptoms. These compounds possess a wide spectrum of positive health effects evidenced by in vitro studies, characterized by their involvement in antioxidant defenses, cell proliferation, and gene expression. The present review analyzes the available data about the different types of nutraceuticals and their potential effectiveness as adjuvant therapy of IBD, with particular emphasis to UC.
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Cite this article as:
The Significant Role of Nutraceutical Compounds in Ulcerative Colitis Treatment, Current Medicinal Chemistry 2022; 29 (24) . https://dx.doi.org/10.2174/0929867329666211227121321
DOI https://dx.doi.org/10.2174/0929867329666211227121321 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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