Title:Selenosemicarbazone Metal Complexes as Potential Metal-based
Drugs
Volume: 30
Issue: 5
关键词:
硒化脲，金属基药物，抗肿瘤，抗菌，抗寄生虫，金属配合物
摘要: The discovery of the anticancer activity of cisplatin has marked the emergence
of modern Inorganic Medicinal Chemistry. This field of research is concerned with the
application of inorganic compounds to therapy or diagnosis of disease. In particular, metal
coordination of bioactive ligands has gained recognition in drug design. The interaction
between transition metal ions and the organic drugs could enhance their diagnostic
and therapeutic potentials by improving the stability and/or bioavailability or by achieving
a metal-drug synergism through a dual or multiple mechanisms of action. The isosteric
replacement of sulfur by selenium in thiosemicarbazones leads to selenosemicarbazones.
This class of compounds exhibits numerous biological activities like antitumor, antimicrobial,
antiviral, etc. and, in most cases, they were more pronounced in comparison
to the sulfur analogues. On the other hand, while the effect of transition metal complexation
on the biological activity of thiosemicarbazones has been widely studied, the pharmacological
activity of the corresponding metal-selenosemicarbazone compounds has been
less explored. In this work, the most relevant results related to the selenosemicarbazone
metal complexes as potential metal-based drugs have been reviewed.
