Title:Regulation of Homeostasis by Neuropeptide Y: Involvement in Food
Intake
Volume: 29
Issue: 23
关键词:
摄食，暴饮暴食，NPY, NPY受体，肥胖，促食肽，单核苷酸多态性。
摘要: Obesity leads to several metabolic disorders and, unfortunately, current pharmacological
treatments for obesity are not very effective. In feeding mechanisms, the hypothalamus
and some neuropeptides play an important role. Many data show that neuropeptide
Y (NPY) is involved in these mechanisms. The aim of this review is to update
the physiological actions mediated by the orexigenic peptide NPY, via its receptors, in
the control of food intake and to review its involvement in food intake disorders. The relationships
between NPY and other substances involved in food intake mechanisms, hypothalamic
and extra-hypothalamic pathways involved in feeding and the potential pharmacological
strategies to treat obesity will be discussed. Some research lines, focused on
NPY, to be developed in the future are suggested. Neuropeptide systems are associated
with redundancy and then therapies directed against a single target are generally ineffective.
For this reason, other targets for the treatment of obesity are mentioned. It seems
that combination therapies are the best option for successful anti-obesity treatments: new
and more specific NPY receptor antagonists must be tested as anti-obesity drugs alone
and in combination therapies.
