Title:Correction of Androgen Deficiency in Men with Type 2 Diabetes
Volume: 17
Issue: 1
Author(s): Volodymyr Pankiv , Tetyana Yuzvenko, Nazarii Kobyliak*Ivan Pankiv
Affiliation:
- Department of Endocrinology, Bogomolets National Medical University,
Kyiv, Ukraine
- Medical Laboratory CSD, Kyiv, Ukraine
Keywords:
Type 2 diabetes, androgen deficiency, testosterone undecanoate, metabolic disorders, estradiol, sexual dysfunction, chronic fatigue.
Abstract:
Background: In men with low levels of testosterone in the blood, it is believed that the
symptoms can be regarded as an association between testosterone deficiency syndrome and related
comorbidities.
Aim: To investigate the effectiveness of testosterone therapy in patients with type 2 diabetes (T2D)
and androgen deficiency.
Materials and Methods: Testosterone replacement therapy was carried out in 26 men with T2D
and clinically or laboratory-confirmed androgen deficiency. The age of the subjects ranged from 35
to 69 years old. Laboratory studies included determinations of the concentration of the hormones
estradiol, luteinizing hormone (LH), and prostate-specific antigen (PSA). The observation period
was 9 months.
Results: The average level of total blood testosterone in the subjects before treatment was 9.4 mol/l
and was likely lower than that of the control group (19.3 ± 1.6 nmol/l). The levels of total testosterone
in the subjects ranged from 3.9 nmol/l to 10.7 nmol/l, and hormone levels measuring less
than 8.0 nmol/l were observed in only 11 patients. After a course of testosterone replacement therapy,
a stabilization in total testosterone levels at the level of reference values (as compared to the
start of treatment) was observed in the blood of men with T2D after 9 months of observation and
the administration of the fourth injection (16.83 ± 0.75 nmol/l).
Conclusion: The use of long-acting injectable testosterone undecanoate leads to normalization of
total testosterone levels in the blood of men with T2D and androgen deficiency, and LH levels in these
patients are unlikely to change.
