Title:Update on the Biological Relevance of Lysine Acetylation as a Novel
Drug Target in Trypanosomatids
Volume: 29
Issue: 20
Author(s): Gonzalo Martinez Peralta, Esteban Serra*Victoria Lucia Alonso*
Affiliation:
- Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina
- Instituto
de Biología Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina
- Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina
- Instituto
de Biología Molecular y Celular de Rosario (IBR-CONICET), Rosario, Argentina
Keywords:
Acetylation, acetyltransferases, deacetylases, acetylome, trypanosomatids, cytoskeleton.
Abstract: The number of acetylated proteins identified from bacteria to mammals has
grown exponentially in the last ten years, and it is now accepted that acetylation is a key
component in most eukaryotic signaling pathways and is as important as phosphorylation.
The enzymes involved in this process are well described in mammals; acetyltransferases
and deacetylases are found inside and outside the nuclear compartment and have
different regulatory functions. In trypanosomatids, several of these enzymes have been
described and are postulated to be novel antiparasitic targets for the rational design of
drugs. In this review article, we present an update of the most important known acetylated
proteins in trypanosomatids, analyzing the acetylomes available. Also, we summarize
the information available regarding acetyltransferases and deacetylases in trypanosomes
and their potential use as chemotherapeutic targets.
