Title:A New Method for the Synthesis of N,N-Diethyl-m-Methylbenzamide from
m-Toluic Acid and Diethylamine Using 1,1'-Carbonyl-di-(1,2,4-triazole)
(CDT) as Coupling Agent
Volume: 19
Issue: 9
Author(s): Duc Thinh Pham, Van Thu Nguyen, Binh Duong Vu*Dinh Chau Phan*
Affiliation:
- Vietnam Military Medical University, Ha Dong district, Hanoi 12108, Vietnam
- School of Chemical Engineering,
Hanoi University of Science and Technology, Haibatrung District, Hanoi 11600, Vietnam
Keywords:
m-toluic acid, N, N-diethyl-m-toluamide, coupling agent, insect repellent, protect, synthesis.
Abstract: A new, simple method for the synthesis of N,N-diethyl-m-methylbenzamide (DEET)
from m-toluic acid and diethylamine using 1,1'-carbonyl-di-(1,2,4-triazole) (CDT) as a coupling
agent has been performed. The basic principles of activated carbonyls have been explored with
the ability to prepare new amides easily. All reaction by-products are water-soluble as well as
removed by filtration, the reaction could be purified easily in an aqueous solution by liquid-liquid
extraction, and the product DEET was high purity. This experimental efficiency is about 94-95%,
purity (HPLC): 97-98%.