Title:Polyphenols and Stem Cells for Neuroregeneration in Parkinson’s Disease and
Amyotrophic Lateral Sclerosis
Volume: 28
Issue: 10
Author(s): Shweta Goyal, Brashket Seth and Rajnish K. Chaturvedi*
Affiliation:
- Developmental Toxicology Laboratory, Systems Toxicology and Health Risk Assessment Group, CSIR-Indian Institute of Toxicology
Research (CSIR-IITR), Vishvigyan Bhavan, 31, Mahatma Gandhi Marg, Lucknow, Uttar Pradesh 226001, India
- Academy of
Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh 201002, India
Keywords:
Neurodegenerative diseases, stem cell, neurodegeneration, polyphenols, neuroregeneration, therapeutics.
Abstract: Parkinson’s disease (PD) and Amyotrophic lateral sclerosis (ALS) are neurological disorders pathologically
characterized by chronic degeneration of dopaminergic neurons and motor neurons, respectively.
There is still no cure or effective treatment against the disease progression and most of the treatments are symptomatic.
The present review offers an overview of the different factors involved in the pathogenesis of these diseases.
Subsequently, we focused on the recent advanced studies of dietary polyphenols and stem cell therapies,
which have made it possible to slow down the progression of neurodegeneration. To date, stem cells and different
polyphenols have been used for the directional induction of neural stem cells into dopaminergic neurons
and motor neurons. We have also discussed their involvement in the modulation of different signal transduction
pathways and growth factor levels in various in vivo and in vitro studies. Likewise stem cells, polyphenols also
exhibit the potential of neuroprotection by their anti-apoptotic, anti-inflammatory, and anti-oxidant properties
regulating the growth factors levels and molecular signaling events. Overall this review provides a detailed insight
into recent strategies that promise the use of polyphenol with stem cell therapy for the possible treatment
of PD and ALS.
