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General Review Article

神经紧张素能系统：癌症治疗的一个目标

卷 29, 期 18, 2022

发表于: 12 January, 2022

页: [3231 - 3260] 页: 30

弟呕挨: 10.2174/0929867328666211027124328

价格: $65

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摘要

背景：在过去的几年中，关于多肽参与癌症的科学兴趣有所增加。在肿瘤细胞中，多肽及其受体的过表达是已知的，并提出了治疗癌症的新的治疗靶点。神经紧张素能系统的过表达与不良预后、肿瘤大小、更高的肿瘤侵袭性、复发风险增加和对化疗药物的敏感性更差相关。目的：本综述的目的是更新有关神经紧张素能系统参与癌症的研究结果，以提出针对该系统的抗癌治疗策略。神经紧张素(NT)前体、NT及其受体(NTR)，以及神经紧张素能系统在肺、乳腺癌、前列腺、胃、结肠、肝癌和胰腺癌、胶质母细胞瘤、神经内分泌肿瘤和b细胞白血病中的作用，以及NT介导的信号通路。未来将提出一些研究思路，如调节NT前体表达的分子，饮食在肿瘤发展中的影响，NT激活的分子和信号通路，以及针对神经紧张素能系统的抗肿瘤治疗策略。结论：NT通过NTR发挥致癌（肿瘤细胞增殖、侵袭、迁移、血管生成）和抗凋亡作用，而NTR拮抗剂则抑制这些作用。NTR表达可作为诊断工具/治疗靶点，而NTR拮抗剂作为抗肿瘤药物可作为治疗NTR过表达肿瘤的一种治疗策略。

关键词: 神经紧张素，神经紧张素受体拮抗剂，肿瘤，肺、乳腺、前列腺、胃肠、肝脏，信号通路。

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