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Review Article

Clinical Practice of Umbilical Cord Blood Stem Cells in Transplantation and Regenerative Medicine - Prodigious Promise for Imminent Times

Author(s): Suman Kumar Ray and Sukhes Mukherjee*

Volume 16, Issue 1, 2022

Published on: 01 December, 2021

Page: [16 - 34] Pages: 19

DOI: 10.2174/1872208315666211026103227

Price: $65

Open Access Journals Promotions 2
Abstract

The umbilical cord blood is usually disposed of as an unwanted material after parturition; however, today, it is viewed as a regenerative medication so as to create the organ tissues. This cord blood gathered from the umbilical cord is made up of mesenchymal stem cells, hematopoietic stem cells, and multipotent non-hematopoietic stem cells having many therapeutic effects as these stem cells are utilized to treat malignancies, hematological ailments, inborn metabolic problem, and immune deficiencies. Presently, numerous clinical applications for human umbilical cord blood inferred stem cells, as stem cell treatment initiate new research. These cells are showing such a boon to stem cell treatment; it is nevertheless characteristic that the prospect of conservation of umbilical cord blood is gaining impetus. Current research works have demonstrated that about 80 diseases, including cancer, can be treated or relieved utilizing umbilical cord blood stem cells, and every year, many transplants have been effectively done around the world. However, in terms of factors, including patient selection, cell preparation, dosing, and delivery process, the treatment procedure for therapy with minimally manipulated stem cells can be patented. It is also worth thinking about how this patent could affect cord blood banks. Meanwhile, the utilization of cord blood cells is controversial and adult-derived cells may not be as successful, so numerous clinicians have begun working with stem cells that are acquired from umbilical cord blood. This review epitomizes a change in outlook from what has been completed with umbilical cord blood cell research and cord blood banking on the grounds that cord blood cells do not require much in the method of handling for cryopreservation or for transplantation in regenerative medicine.

Keywords: Umbilical cord blood, stem cells, therapeutics, cord blood bank, patent, regenerative medicine.

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[1]
Rogers I, Casper RF. Umbilical cord blood stem cells. Best Pract Res Clin Obstet Gynaecol 2004; 18(6): 893-908.
[http://dx.doi.org/10.1016/j.bpobgyn.2004.06.004] [PMID: 15582545]
[2]
Moise KJ Jr. Umbilical cord stem cells. Obstet Gynecol 2005; 106(6): 1393-407.
[http://dx.doi.org/10.1097/01.AOG.0000188388.84901.e4] [PMID: 16319269]
[3]
Sanberg PR, Willing AE, Garbuzova-Davis S, et al. Umbilical cord blood-derived stem cells and brain repair. Ann N Y Acad Sci 2005; 1049: 67-83.
[http://dx.doi.org/10.1196/annals.1334.008] [PMID: 15965108]
[4]
Watt SM, Contreras M. Stem cell medicine: umbilical cord blood and its stem cell potential. Semin Fetal Neonatal Med 2005; 10(3): 209-20.
[http://dx.doi.org/10.1016/j.siny.2005.02.001] [PMID: 15927877]
[5]
Czechowicz A, Weissman IL. Purified hematopoietic stem cell transplantation: The next generation of blood and immune replacement. Hematol Oncol Clin North Am 2011; 25(1): 75-87.
[http://dx.doi.org/10.1016/j.hoc.2010.11.006] [PMID: 21236391]
[6]
Zhao K, Liu Q. The clinical application of mesenchymal stromal cells in hematopoietic stem cell transplantation. J Hematol Oncol 2016; 9(1): 46.
[http://dx.doi.org/10.1186/s13045-016-0276-z] [PMID: 27193054]
[7]
Morgan RA, Gray D, Lomova A, Kohn DB. Hematopoietic stem cell gene therapy: Progress and lessons learned. Cell Stem Cell 2017; 21(5): 574-90.
[http://dx.doi.org/10.1016/j.stem.2017.10.010] [PMID: 29100011]
[8]
Butler MG, Menitove JE. Umbilical cord blood banking: An update. J Assist Reprod Genet 2011; 28(8): 669-76.
[http://dx.doi.org/10.1007/s10815-011-9577-x] [PMID: 21617932]
[9]
Roura S, Pujal JM, Gálvez-Montón C, Bayes-Genis A. The role and potential of umbilical cord blood in an era of new therapies: A review. Stem Cell Res Ther 2015; 6: 123.
[http://dx.doi.org/10.1186/s13287-015-0113-2] [PMID: 26133757]
[10]
Matsumoto MM, Matthews KRW. A need for renewed and cohesive US policy on cord blood banking. Stem Cell Rev Rep 2015; 11(6): 789-97.
[http://dx.doi.org/10.1007/s12015-015-9613-9] [PMID: 26239848]
[11]
Ballen KK, Verter F, Kurtzberg J. Umbilical cord blood donation: public or private? Bone Marrow Transplant 2015; 50(10): 1271-8.
[http://dx.doi.org/10.1038/bmt.2015.124] [PMID: 26030051]
[12]
McCullough J, McKenna D, Kadidlo D, Schierman T, Wagner J. Issues in the quality of umbilical cord blood stem cells for transplantation. Transfusion 2005; 45(6): 832-41.
[http://dx.doi.org/10.1111/j.1537-2995.2005.04265.x] [PMID: 15934980]
[13]
Tamburini A, Malerba C, Picardi A, Amadori S, Calugi A. Placental/umbilical cord blood: experience of st. Eugenio Hospital collection center. Transplant Proc 2005; 37(6): 2670-2.
[http://dx.doi.org/10.1016/j.transproceed.2005.06.065] [PMID: 16182780]
[14]
Sanchez-Ramos JR. Neural cells derived from adult bone marrow and umbilical cord blood. J Neurosci Res 2002; 69(6): 880-93.
[http://dx.doi.org/10.1002/jnr.10337] [PMID: 12205681]
[15]
Zakrzewski W, Dobrzyński M, Szymonowicz M, Rybak Z. Stem cells: past, present, and future. Stem Cell Res Ther 2019; 10(1): 68.
[http://dx.doi.org/10.1186/s13287-019-1165-5] [PMID: 30808416]
[16]
Erices A, Conget P, Minguell JJ. Mesenchymal progenitor cells in human umbilical cord blood. Br J Haematol 2000; 109(1): 235-42.
[http://dx.doi.org/10.1046/j.1365-2141.2000.01986.x] [PMID: 10848804]
[17]
Goodwin HS, Bicknese AR, Chien SN, Bogucki BD, Quinn CO, Wall DA. Multilineage differentiation activity by cells isolated from umbilical cord blood: expression of bone, fat, and neural markers. Biol Blood Marrow Transplant 2001; 7(11): 581-8.
[http://dx.doi.org/10.1053/bbmt.2001.v7.pm11760145] [PMID: 11760145]
[18]
Song S, Sanchez-Ramos J. Preparation of neural progenitors from bone marrow and umbilical cord blood. Methods Mol Biol 2002; 198: 79-88.
[http://dx.doi.org/10.1385/1-59259-186-8:079] [PMID: 11951643]
[19]
Abbattista MR, Schena FP. Stem cells and kidney diseases. Minerva Med 2004; 95(5): 411-8.
[PMID: 15467516]
[20]
Humes HD, Szczypka MS. Advances in cell therapy for renal failure. Transpl Immunol 2004; 12(3-4): 219-27.
[http://dx.doi.org/10.1016/j.trim.2003.12.015] [PMID: 15157916]
[21]
Ma N, Stamm C, Kaminski A, et al. Human cord blood cells induce angiogenesis following myocardial infarction in NOD/scid-mice. Cardiovasc Res 2005; 66(1): 45-54.
[http://dx.doi.org/10.1016/j.cardiores.2004.12.013] [PMID: 15769447]
[22]
Peterson DE. New strategies for management of oral mucositis in cancer patients. J Support Oncol 2006; 4(2)(Suppl. 1): 9-13.
[PMID: 16499139]
[23]
Uçüncü H, Ertekin MV, Yörük O, et al. Vitamin E and L-carnitine, separately or in combination, in the prevention of radiation-induced oral mucositis and myelosuppression: A controlled study in a rat model. J Radiat Res (Tokyo) 2006; 47(1): 91-102.
[http://dx.doi.org/10.1269/jrr.47.91] [PMID: 16571922]
[24]
Valeh M, Kargar M, Mansouri A, et al. Factors affecting the incidence and severity of oral mucositis following hematopoietic stem cell transplantation. Int J Hematol Oncol Stem Cell Res 2018; 12(2): 142-52.
[PMID: 30233777]
[25]
Hatzimichael E, Tuthill M. Hematopoietic stem cell transplantation. Stem Cells Cloning 2010; 3: 105-17.
[PMID: 24198516]
[26]
Fabricius WA, Ramanathan M. Review on haploidentical hematopoietic cell transplantation in patients with hematologic malignancies. Adv Hematol 2016; 2016: 5726132.
[http://dx.doi.org/10.1155/2016/5726132] [PMID: 27034676]
[27]
Smith AR, Wagner JE. Alternative haematopoietic stem cell sources for transplantation: place of umbilical cord blood. Br J Haematol 2009; 147(2): 246-61.
[http://dx.doi.org/10.1111/j.1365-2141.2009.07828.x] [PMID: 19796274]
[28]
Shearer WT, Lubin BH, Cairo MS, Notarangelo LD. Cord blood banking for potential future transplantation. Pediatrics 2017; 140(5): e20172695.
[http://dx.doi.org/10.1542/peds.2017-2695] [PMID: 29084832]
[29]
Gluckman E. Ten years of cord blood transplantation: from bench to bedside. Br J Haematol 2009; 147(2): 192-9.
[http://dx.doi.org/10.1111/j.1365-2141.2009.07780.x] [PMID: 19796268]
[30]
Mehta RS, Shpall EJ. Ex vivo cord blood manipulation: Methods, data, and challenges. In: Horwitz M, Chao N, Eds. Cord Blood Transplantations. Cham: Springer International Publishing 2017; pp. 71-85.
[http://dx.doi.org/10.1007/978-3-319-53628-6_5]
[31]
Dessels C, Alessandrini M, Pepper MS. Factors influencing the umbilical cord blood stem cell industry: An evolving treatment landscape. Stem Cells Transl Med 2018; 7(9): 643-50.
[http://dx.doi.org/10.1002/sctm.17-0244] [PMID: 29777574]
[32]
Kurtzberg J, Lyerly AD, Sugarman J. Untying the Gordian knot: policies, practices, and ethical issues related to banking of umbilical cord blood. J Clin Invest 2005; 115(10): 2592-7.
[http://dx.doi.org/10.1172/JCI26690] [PMID: 16200191]
[33]
Boyse EA, Broxmeyer HE, Douglas GW. Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood. United States Patent and Trademark Office United States Patent US 5004681A, 1987.
[34]
Boyse EA, Broxmeyer HE, Douglas GW. Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use. United States Patent US5192553A, 1988.
[35]
Hessel SR, Young HT, Katz M. Umbilical cord clamping, cutting, and blood collecting device and method. United States Patent US5415665A, 1991.
[36]
Emerson SG, Clarke MF, Palsson BO. Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells. United States Patent US6326198B1, 1997.
[37]
Kraus M, Wilder PT, Friberg J. Selective expansion of target cell populations. United States Patent US6338942B2, 1997.
[38]
Rodgers KE, diZerega GS. Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation. United States Patent US6335195B1, 1998.
[39]
Moore TE, Harris DT, Kramer JO. Computer-based mixed-use registry of placental and umbilical cord stem cells. United States Patent US5993387A, 1999.
[40]
Hariri RJ. Post-partum mammalian placenta, its use and placental stem cells therefrom. United States Patent US20030032179A1, 2002.
[41]
Hariri RJ. Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells. Australia Patent. AU2008249204B2, 2003.
[42]
Takebe N. Methods for collecting and using placenta cord blood stem cells. United States Patent US10548926B2, 2007.
[43]
Heidaran MA, Johnson KE, Hariri RJ. Use of umbilical cord blood in the treatment of premature birth complications. European Patent Office EP2217329B1, 2008.
[44]
Riordan NH, Ichim TE. Compositions and methods of stem cell therapy for autism. WIPO (PCT) Patent. WO2009046377A2, 2008.
[45]
Riordan NH, Ichim TE. Stem cell therapy for the treatment of autism and other disorders. United States Patent. US20160263162A1, 2008.
[46]
Kurtsburg J, Dawson G, Troy J, Sun J. Methods for the treatment of autism spectrum disorders. South Korea Patent KR20190124300A, 2018.
[47]
Kurtsburg J, Dawson G, Troy J, Sun J. Methods for the treatment of autism spectrum disorders. WIPO (PCT). Patent WO2018169952A1, 2018.
[48]
Kurtzberg J, Sun J. Methods of treating cerebral palsy using high dose allogeneic umbilical cord blood. United States Patent US20200016213A1, 2019.
[49]
Kurtzberg J, Dawson G, Sun J. Methods of treating autism spectrum disorders using human umbilical cord tissue-derived mesenchymal stromal cells. WIPO (PCT) Patent WO2019195506A1, 2019.
[50]
Wei D, Li Z, Yabin Z, Xueping H, Junye Y, Junling H. Method for preparing PRP from umbilical cord blood and application of prepared PRP in preparation of medicine for treating diabetic hard-to-heal wound. China Patent CN112336748A, 2020.
[51]
Jiangtao Z, Yuqi H, Bin C. Method for delaying premature ovarian failure by adopting umbilical cord blood stem cell infusion. China Patent CN111973634A, 2020.
[52]
Wei L, Xikai W, Qingyi Z. Method for separating and preparing umbilical cord blood stem cells. China Patent CN112029726A, 2020.
[53]
Junhe Z, Shujie C, Jihong Z, Jianhui G, Linlin S, Wenwen Y. Culture method of human umbilical cord blood mesenchymal stem cells. China Patent CN111235100A, 2020.
[54]
Xiaofei W, Lei S. Device for cleaning unfrozen umbilical cord blood hematopoietic stem cells and unfreezing cleaning and storing method based on device. China Patent CN111701097A, 2020.
[55]
Rui L, Wei W, Congying S. Autologous umbilical cord blood treatment method for preventing premature infant complications and application thereof. China Patent CN111514392A, 2020.
[56]
Tao Z, Bo C. Composition for promoting osteogenic differentiation of umbilical cord blood stem cells and application thereof. China Patent CN112430269A, 2021.
[57]
Weiss ML, Troyer DL. Stem cells in the umbilical cord. Stem Cell Rev 2006; 2(2): 155-62.
[http://dx.doi.org/10.1007/s12015-006-0022-y] [PMID: 17237554]
[58]
Pittenger MF, Discher DE, Péault BM, Phinney DG, Hare JM, Caplan AI. Mesenchymal stem cell perspective: cell biology to clinical progress. NPJ Regen Med 2019; 4: 22.
[http://dx.doi.org/10.1038/s41536-019-0083-6] [PMID: 31815001]
[59]
Kuroda Y, Dezawa M. Mesenchymal stem cells and their subpopulation, pluripotent muse cells, in basic research and regenerative medicine. Anat Rec (Hoboken) 2014; 297(1): 98-110.
[http://dx.doi.org/10.1002/ar.22798] [PMID: 24293378]
[60]
Elchalal U, Fasouliotis SJ, Shtockheim D, et al. Postpartum umbilical cord blood collection for transplantation: A comparison of three methods. Am J Obstet Gynecol 2000; 182(1 Pt 1): 227-32.
[http://dx.doi.org/10.1016/S0002-9378(00)70517-5] [PMID: 10649183]
[61]
Harris DT. Collection, processing, and banking of umbilical cord blood stem cells for clinical use in transplantation and regenerative medicine. Lab medicine 2008; 39: 3.
[http://dx.doi.org/10.1309/64QG394K1M639L8A]
[62]
Shlebak AA, Marley SB, Roberts IAG, Davidson RJ, Goldman JM, Gordon MY. Optimal timing for processing and cryopreservation of umbilical cord haematopoietic stem cells for clinical transplantation. Bone Marrow Transplant 1999; 23(2): 131-6.
[http://dx.doi.org/10.1038/sj.bmt.1701551] [PMID: 10197797]
[63]
Mousavi SH, Zarrabi M, Abroun S, Ahmadipanah M, Abbaspanah B. Umbilical cord blood quality and quantity: Collection up to transplantation. Asian J Transfus Sci 2019; 13(2): 79-89.
[http://dx.doi.org/10.4103/ajts.AJTS_124_18] [PMID: 31896912]
[64]
Harris D. Long-term frozen storage of stem cells: Challenges and solutions. J Biorepos Sci App Med 2016; 4: 9-20.
[http://dx.doi.org/10.2147/BSAM.S90142]
[65]
Kolios G, Moodley Y. Introduction to stem cell sand regenerative medicine. Thematic review series. Respiration 2013; 85: 3-10.
[http://dx.doi.org/10.1159/000345615] [PMID: 23257690]
[66]
Zwaka TP, Thomson JA. A germ cell origin of embryonic stem cells. Development 2005; 132(2): 227-33.
[http://dx.doi.org/10.1242/dev.01586] [PMID: 15623802]
[67]
Rathjen J. The states of pluripotency: Pluripotent lineage development inthe embryo and in the dish. ISRN Stem Cells 2014; 208067.
[http://dx.doi.org/10.1155/2014/208067]
[68]
Leist M, Bremer S, Brundin P, et al. The biological and ethical basis of the use of human embryonic stem cells for in vitro test systems or cell therapy. Altex 2008; 25(3/08): 163-90.
[http://dx.doi.org/10.14573/altex.2008.3.163]
[69]
Lo B, Parham L. Ethical issues in stem cell research. Endocr Rev 2009; 30(3): 204-13.
[http://dx.doi.org/10.1210/er.2008-0031] [PMID: 19366754]
[70]
Dittrich R, Beckmann MW, Würfel W. Non-embryo-destructive extraction of pluripotent embryonic stem cells: Implications for regenerative medicine and reproductive medicine. Geburtshilfe Frauenheilkd 2015; 75(12): 1239-42.
[http://dx.doi.org/10.1055/s-0035-1558183] [PMID: 26726264]
[71]
Khan FA, Almohazey D, Alomari M, Almofty SA. Isolation, culture, and functional characterization of humanEmbryonic stem cells: Current trends and challenges. Stem Cells Int 2018; 1429357.
[http://dx.doi.org/10.1155/2018/1429351]
[72]
Lerou PH, Daley GQ. Therapeutic potential of embryonic stem cells. Blood Rev 2005; 19(6): 321-31.
[http://dx.doi.org/10.1016/j.blre.2005.01.005] [PMID: 16275420]
[73]
Cedar SH, Cooke JA, Patel MR, Luo Z, Minger SL. The therapeutic potential of human embryonic stem cells. Indian J Med Res 2007; 125(1): 17-24.
[PMID: 17332653]
[74]
Watt FM, Driskell RR. The therapeutic potential of stem cells. Philos Trans R Soc Lond B Biol Sci 2010; 365(1537): 155-63.
[http://dx.doi.org/10.1098/rstb.2009.0149] [PMID: 20008393]
[75]
Pranke P, Failace RR, Allebrandt WF, Steibel G, Schmidt F, Nardi NB. Hematologic and immunophenotypic characterization of human umbilical cord blood. Acta Haematol 2001; 105(2): 71-6.
[http://dx.doi.org/10.1159/000046537] [PMID: 11408707]
[76]
Dalle JH, Menezes J, Wagner E, et al. Characterization of cord blood natural killer cells: implications for transplantation and neonatal infections. Pediatr Res 2005; 57(5 Pt 1): 649-55.
[http://dx.doi.org/10.1203/01.PDR.0000156501.55431.20] [PMID: 15718362]
[77]
Sarvaria A, Jawdat D, Madrigal JA, Saudemont A. Umbilical cord blood natural killer cells, their characteristics, and potential clinical applications. Front Immunol 2017; 8: 329.
[http://dx.doi.org/10.3389/fimmu.2017.00329] [PMID: 28386260]
[78]
Boissel L, Tuncer HH, Betancur M, Wolfberg A, Klingemann H. Umbilical cord mesenchymal stem cells increase expansion of cord blood natural killer cells. Biol Blood Marrow Transplant 2008; 14(9): 1031-8.
[http://dx.doi.org/10.1016/j.bbmt.2008.06.016] [PMID: 18721766]
[79]
Luevano M, Domogala A, Blundell M, et al. Frozen cord blood hematopoietic stem cells differentiate into higher numbers of functional natural killer cells in vitro than mobilized hematopoietic stem cells or freshly isolated cord blood hematopoietic stem cells. PLoS One 2014; 9(1): e87086.
[http://dx.doi.org/10.1371/journal.pone.0087086] [PMID: 24489840]
[80]
Mahla RS. Stem cells application in regenerative medicine and disease threpeutics. Int J Cell Biol 2016; 2016(7): 6940283.
[http://dx.doi.org/10.1155/2016/6940283] [PMID: 27516776]
[81]
Passier R, Mummery C. Origin and use of embryonic and adult stem cells in differentiation and tissue repair. Cardiovasc Res 2003; 58(2): 324-35.
[http://dx.doi.org/10.1016/S0008-6363(02)00770-8] [PMID: 12757867]
[82]
Guasch G, Fuchs E. Mice in the world of stem cell biology. Nat Genet 2005; 37(11): 1201-6.
[http://dx.doi.org/10.1038/ng1667] [PMID: 16254567]
[83]
Philip J, Kushwaha N, Chatterjee T, Mallhi RS. Optimizing cord blood collections: Assessing the role of maternal and neonatal factors. Asian J Transfus Sci 2015; 9(2): 163-7.
[http://dx.doi.org/10.4103/0973-6247.162714] [PMID: 26420937]
[84]
Sato N, Fricke C, McGuckin C, et al. Cord blood processing by a novel filtration system. Cell Prolif 2015; 48(6): 671-81.
[http://dx.doi.org/10.1111/cpr.12217] [PMID: 26456086]
[85]
Basford C, Forraz N, Habibollah S, Hanger K, McGuckin C. The cord blood separation league table: A comparison of the major clinical grade harvesting techniques for cord blood stem cells. Int J Stem Cells 2010; 3(1): 32-45.
[http://dx.doi.org/10.15283/ijsc.2010.3.1.32] [PMID: 24855539]
[86]
Rubinstein P, Rosenfield RE, Adamson JW, Stevens CE. Stored placental blood for unrelated bone marrow reconstitution. Blood 1993; 81(7): 1679-90.
[http://dx.doi.org/10.1182/blood.V81.7.1679.1679] [PMID: 8096404]
[87]
Harris DT, Schumacher MJ, Rychlik S, et al. Collection, separation and cryopreservation of umbilical cord blood for use in transplantation. Bone Marrow Transplant 1994; 13(2): 135-43.
[PMID: 8205082]
[88]
D’Agati A, Leanza V, Leanza G, Mayada C, Carbonaro A, Pafumi C. Stem cell separation from cord blood. 2017; 6(2): 24-6.
[89]
Harris DT, Schumacher MJ, Locascio J, et al. Phenotypic and functional immaturity of human umbilical cord blood T lymphocytes. Proc Natl Acad Sci USA 1992; 89(21): 10006-10.
[http://dx.doi.org/10.1073/pnas.89.21.10006] [PMID: 1438190]
[90]
Kurtzberg J. A history of cord blood banking and transplantation. Stem Cells Transl Med 2017; 6(5): 1309-11.
[http://dx.doi.org/10.1002/sctm.17-0075] [PMID: 28456005]
[91]
Dastur A. Umbilical cord blood banking. J Obstet Gynaecol India 2005; 55(6): 502-4.
[92]
Sivakumaran N, Rathnayaka IR, Shabbir R, Wimalsinghe SS, Jayakody JAS, Chandrasekaran M. Umbilical cord blood banking and its therapeutic uses. Int J Sci Res Innovat Technol 2018; 5(1): 1.
[93]
2020. Available from: https://bioinformant.com/top-ten-most-influential-cord-blood-banks-worldwide/ last retrieved date: 17thjune 2020
[94]
Chen A. Presentation: The Commercialization of Umbilical Cord Blood Banking in China and its Operational Challenges. World Cord Blood Congress.
[95]
Wire B. AuxoCell Laboratories Licenses Umbilical Cord Tissue Stem Cell Service to Brazil’s CordVida | Business Wire. Businesswirecom Available from: http://www.businesswire.com/news/home/20120606005447/en/AuxoCell-Laboratories-Licenses-Umbilical-Cord-Tissue-Stem#.VGDHAfnF91U [Accessed 17th June,2020].
[96]
Prnewswire.com. With record cord blood collections, Americord aims for Inc. 2014. Available from: http://www.prnewswire.com/news-releases/with-record-cord-blood-collections-americord-aims- for-inc-500-240158921.html
[97]
AABB.org. AABB Accredited Cord Blood (CB) Facilities. 2014. Available from: http://www.aabb.org/sa/facilities/celltherapy/Pages/CordBloodAccrFac.aspx
[98]
Hauskeller C, Beltrame L. The hybrid bioeconomy of umbilical cord blood banking: Re-examining the narrative of opposition between public and private services. Biosocieties 2016; 11(4): 415-34.
[http://dx.doi.org/10.1057/biosoc.2015.45]
[99]
Available from: https://parentsguidecordblood.org/en/family-banking/india
[100]
Rahman J. Umbilical cord blood (stem cell) banking. J Bangladesh Coll Phys Surg 2009; 27(1): 39-44.
[http://dx.doi.org/10.3329/jbcps.v27i1.4242]
[101]
Troyer DL, Weiss ML. Concise review: Wharton’s jelly-derived cells are a primitive stromal cell population stem cells 2008; 26(3): 591-9.
[102]
Shi Q, Gao J, Jiang Y, et al. Differentiation of human umbilical cord Wharton’s jelly-derived mesenchymal stem cells into endometrial cells. Stem Cell Res Ther 2017; 8(1): 246.
[http://dx.doi.org/10.1186/s13287-017-0700-5] [PMID: 29096715]
[103]
Marino L, Castaldi MA, Rosamilio R, et al. Mesenchymal stem cells from the Wharton’s Jelly of the human umbilical cord: Biological properties and therapeutic potential. Int J Stem Cells 2019; 12(2): 218-26.
[http://dx.doi.org/10.15283/ijsc18034] [PMID: 31022994]
[104]
Zoe. Umbilical Cord Tissue Stem Cells – more valuable than you think. 2016. Available from: http://cells4life.com/2016/08/umbilical-cord-tissue-stem-cellsmore-valuable-than-you-think/
[105]
Erceg S, Ronaghi M, Stojković M. Human embryonic stem cell differentiation toward regional specific neural precursors. Stem Cells 2009; 27(1): 78-87.
[http://dx.doi.org/10.1634/stemcells.2008-0543] [PMID: 18845761]
[106]
Tipnis S, Viswanathan C. Umbilical cord matrix derived mesenchymal stem cells can change the cord blood transplant scenario. Int J Stem Cells 2010; 3(2): 103-18.
[http://dx.doi.org/10.15283/ijsc.2010.3.2.103] [PMID: 24855548]
[107]
Nagamura-Inoue T, He H. Umbilical cord-derived mesenchymal stem cells: Their advantages and potential clinical utility. World J Stem Cells 2014; 6(2): 195-202.
[http://dx.doi.org/10.4252/wjsc.v6.i2.195] [PMID: 24772246]
[108]
Heo JS, Choi Y, Kim HS, Kim HO. Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med 2016; 37(1): 115-25.
[http://dx.doi.org/10.3892/ijmm.2015.2413] [PMID: 26719857]
[109]
Bárcia RN, Santos JM, Filipe M, et al. What makes umbilical cord tissue-derived mesenchymal stromal cells superior immunomodulators when compared to bone marrow derived mesenchymal stromal cells? Stem Cells Int 2015; 2015: 583984.
[http://dx.doi.org/10.1155/2015/583984] [PMID: 26064137]
[110]
Yousefifard M, Nasirinezhad F, Shardi Manaheji H, Janzadeh A, Hosseini M, Keshavarz M. Human bone marrow-derived and umbilical cord-derived mesenchymal stem cells for alleviating neuropathic pain in a spinal cord injury model. Stem Cell Res Ther 2016; 7: 36.
[http://dx.doi.org/10.1186/s13287-016-0295-2] [PMID: 26957122]
[111]
McKenna D, Sheth J. Umbilical cord blood: current status & promise for the future. Indian J Med Res 2011; 134: 261-9.
[PMID: 21985808]
[112]
Tomblyn MB, Arora M, Baker KS, et al. Myeloablative hematopoietic cell transplantation for acute lymphoblastic leukemia: Analysis of graft sources and long-term outcome. J Clin Oncol 2009; 27(22): 3634-41.
[http://dx.doi.org/10.1200/JCO.2008.20.2960] [PMID: 19581540]
[113]
Prasad VK, Mendizabal A, Parikh SH, et al. Unrelated donor umbilical cord blood transplantation for inherited metabolic disorders in 159 pediatric patients from a single center: influence of cellular composition of the graft on transplantation outcomes. Blood 2008; 112(7): 2979-89.
[http://dx.doi.org/10.1182/blood-2008-03-140830] [PMID: 18587012]
[114]
Benito AI, Diaz MA, González-Vicent M, Sevilla J, Madero L. Hematopoietic stem cell transplantation using umbilical cord blood progenitors: review of current clinical results. Bone Marrow Transplant 2004; 33(7): 675-90.
[http://dx.doi.org/10.1038/sj.bmt.1704405] [PMID: 14981535]
[115]
Lubin BHSW, Shearer WT. Cord blood banking for potential future transplantation. Pediatrics 2007; 119(1): 165-70.
[http://dx.doi.org/10.1542/peds.2006-2901] [PMID: 17200285]
[116]
Shahrokhi S, Menaa F, Alimoghaddam K, McGuckin C, Ebtekar M. Insights and hopes in umbilical cord blood stem cell transplantations. J Biomed Biotechnol 2012; 2012: 572821.
[http://dx.doi.org/10.1155/2012/572821] [PMID: 23258957]
[117]
Galieva LR, Mukhamedshina YO, Arkhipova SS, Rizvanov AA. Human umbilical cord blood cell transplantation in neuroregenerative strategies. Front Pharmacol 2017; 8: 628.
[http://dx.doi.org/10.3389/fphar.2017.00628] [PMID: 28951720]
[118]
Scott CT. The case for stem cell counselors. Stem Cell Reports 2015; 4(1): 1-6.
[http://dx.doi.org/10.1016/j.stemcr.2014.10.016] [PMID: 25483110]
[119]
Zierhut H, Schneider KW. Stem cell transplantation: Genetic counselors as a critical part of the process. Curr Genet Med Rep 2014; 2(2): 39-47.
[http://dx.doi.org/10.1007/s40142-014-0038-6]
[120]
Kirkpatrick B, Hercher L, Facio F, et al. Stem cell research and therapy: the position of the National Society of Genetic Counselors. J Genet Couns 2013; 22(4): 407-10.
[http://dx.doi.org/10.1007/s10897-013-9572-8] [PMID: 23430401]
[121]
Brown KS, Rao MS, Brown HL. The future state of newborn stem cell banking. J Clin Med (Lond) 2019; 8(1): 117.
[122]
Busby H. The meanings of consent to the donation of cord blood stem cells: perspectives from an interview-based study of a public cord blood bank in England Clin Ethics. 2010; 5(1): 22-7.
[http://dx.doi.org/10.1258/ce.2009.009028]
[123]
Chen YH, Xu LP, Liu DH, et al. Comparative outcomes between cord blood transplantation and bone marrow or peripheral blood stem cell transplantation from unrelated donors in patients with hematologic malignancies: A single-institute analysis. Chin Med J (Engl) 2013; 126(13): 2499-503.
[PMID: 23823825]
[124]
Mayani H, Wagner JE, Broxmeyer HE. Cord blood research, banking, and transplantation: Achievements, challenges, and perspectives. Bone Marrow Transplant 2020; 55(1): 48-61.
[http://dx.doi.org/10.1038/s41409-019-0546-9] [PMID: 31089283]
[125]
Parekkadan B, Milwid JM. Mesenchymal stem cells as therapeutics. Annu Rev Biomed Eng 2010; 12: 87-117.
[http://dx.doi.org/10.1146/annurev-bioeng-070909-105309] [PMID: 20415588]
[126]
Tajer P, Pike-Overzet K, Arias S, Havenga M, Staal FJT. Ex vivo expansion of hematopoietic stem cells for therapeutic purposes: Lessons from development and the niche. Cells 2019; 8(2): 169.
[http://dx.doi.org/10.3390/cells8020169] [PMID: 30781676]
[127]
Crippa S, Santi L, Bosotti R, Porro G, Bernardo ME. Bone marrow-derived mesenchymal stromal cells: A novel target to optimize hematopoietic stem cell transplantation protocols in hematological malignancies and rare genetic disorders. J Clin Med 2019; 9(1): 2.
[http://dx.doi.org/10.3390/jcm9010002] [PMID: 31861268]
[128]
Ul Hassan A, Hassan G, Rasool Z. Role of stem cells in treatment of neurological disorder. Int J Health Sci (Qassim) 2009; 3(2): 227-33.
[PMID: 21475541]
[129]
Vishwakarma SK, Bardia A, Tiwari SK, Paspala SA, Khan AA. Current concept in neural regeneration research: NSCs isolation, characterization and transplantation in various neurodegenerative diseases and stroke: A review. J Adv Res 2014; 5(3): 277-94.
[http://dx.doi.org/10.1016/j.jare.2013.04.005] [PMID: 25685495]
[130]
VanderStaay FJ, Arndt SS, Nordquist RE. Evaluation of animal models of neurobehavioral disorders. Behav Brain Funct 2009; 5: 11.
[http://dx.doi.org/10.1186/1744-9081-5-11]
[131]
McDonald CA, Penny TR, Paton MCB, et al. Effects of umbilical cord blood cells, and subtypes, to reduce neuroinflammation following perinatal hypoxic-ischemic brain injury. J Neuroinflammation 2018; 15(1): 47.
[http://dx.doi.org/10.1186/s12974-018-1089-5] [PMID: 29454374]
[132]
Vendrame M, Gemma C, DeMesquita D, Collier L, Bickford PC. Sanberg CD et al. Anti-inflammatory effects of human cord blood cells in a rat model of stroke stem cells and development 2005; 14: 5.
[http://dx.doi.org/10.1089/scd.2005.14.595] [PMID: 16305344]
[133]
Hau S, Reich DM, Scholz M, et al. Evidence for neuroprotective properties of human umbilical cord blood cells after neuronal hypoxia in vitro. BMC Neurosci 2008; 9: 30.
[http://dx.doi.org/10.1186/1471-2202-9-30] [PMID: 18312640]
[134]
Chen CT, Foo NH, Liu WS, Chen SH. Infusion of human umbilical cord blood cells ameliorates hind limb dysfunction in experimental spinal cord injury through anti-inflammatory, vasculogenic and neurotrophic mechanisms. Pediatr Neonatol 2008; 49(3): 77-83.
[http://dx.doi.org/10.1016/S1875-9572(08)60017-0] [PMID: 18947003]
[135]
Arien-Zakay H, Lecht S, Nagler A, Lazarovici P, Arien-Zakay H. Human umbilical cord blood stem cells: rational for use as a neuroprotectant in ischemic brain disease. Int J Mol Sci 2010; 11(9): 3513-28.
[http://dx.doi.org/10.3390/ijms11093513] [PMID: 20957109]
[136]
Sun T, Ma QH. Repairing neural injuries using human umbilical cord blood. Mol Neurobiol 2013; 47(3): 938-45.
[http://dx.doi.org/10.1007/s12035-012-8388-0] [PMID: 23275174]

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