Title:Adiponectin is Inversely Associated with Insulin Resistance in Adolescents
with Nonalcoholic Fatty Liver Disease
Volume: 22
Issue: 6
Author(s): Bin Liu*, Huan Zheng*, Guanghui Liu and Zhiling Li*
Affiliation:
- Department of Neurology, Shanghai Minhang Hospital, Fudan University, Shanghai, China
- Department of Neurology,
Shanghai Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China
- Department
of Cardiology, Worldpath Clinic International, Shanghai, China
- Department of Pharmacy, Shanghai Children’s Hospital,
Shanghai Jiao Tong University, Shanghai, China
Keywords:
Adiponectin, insulin resistance, nonalcoholic fatty liver disease, adolescent, homeostasis model assessment of insulin resistance, adipokines.
Abstract:
Background: Insulin Resistance (IR) is confirmed as a key feature of Nonalcoholic Fatty
Liver Disease (NAFLD) in children and adolescents. Numerous studies report that adiponectin
(APN) levels are inversely associated with the status of IR in adults with NAFLD. This study
aimed to investigate the relationship between serum total APNand Homeostasis Model Assessment
Insulin Resistance (HOMA-IR) in adolescents with NAFLD.
Methods: 382 newly-diagnosed NAFLD adolescents, aged 9-16 years old, were enrolled and divided
into three subgroups according to the APNtertile. Simple and multiple linear regression analyses
were performed to assess the correlation between HOMA-IR and APN in boys and girls, respectively.
Results: The HOMA-IR values tended to decrease in boys according to APN tertiles: 5.6(4.4-7.3)
vs. 5.2(4.6-6.9) vs. 4.9(4.1-5.8) (p<0.01), and there was a significant difference in the HOMA-IR
values among three APN tertile subgroups in girls (p<0.01). Univariate analysis showed that body
mass index, waist circumference, weight-to-height ratio, fasting blood glucose, insulin, triglyceride,
and APN were significantly associated with HOMA-IR in boys (p<0.05). In girls, body mass
index, fasting blood glucose, insulin, total cholesterol, triglyceride, and APN were significantly associated
with HOMA-IR (p<0.05).APN was found to be a significant determinant for HOMA-IR
only in boys (β=-0.147, p<0.01).
Conclusion: Our findings showed that APN was an independent and significant determinant for increased
HOMA-IR in boys with NAFLD. Further studies are needed to explore the underlying
mechanisms.
