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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Letter Article

Facile Preparation of Aryl Nitriles from Aryl Aldehydes in PEG-DME 250

Author(s): Solbe Kang and Jong Chan Lee*

Volume 19, Issue 4, 2022

Published on: 12 January, 2022

Page: [259 - 262] Pages: 4

DOI: 10.2174/1570178618666210909103040

Price: $65

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Abstract

A facile and efficient method is reported for the one-pot transformation of aryl aldehydes to aryl nitriles using hydroxylamine hydrochloride and phosphorus tribromide in PEGDME 250. The conversion of various aryl aldehydes to the corresponding aryl nitriles occurred smoothly in high yields under the present reaction conditions.

Keywords: Aldehydes, aldoxime, nitriles, phosphorus, polyethylene, polyglyme.

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