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Current Neuropharmacology

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ISSN (Print): 1570-159X
ISSN (Online): 1875-6190

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Review Article

The Role of Mitochondrial Genes in Neurodegenerative Disorders

Author(s): Rajesh Kumar, Seetha Harilal, Della Grace Thomas Parambi, S.K. Kanthlal, Md Atiar Rahman, Athanasios Alexiou*, Gaber El-Saber Batiha and Bijo Mathew*

Volume 20, Issue 5, 2022

Published on: 14 March, 2022

Page: [824 - 835] Pages: 12

DOI: 10.2174/1570159X19666210908163839

Price: $65

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Abstract

Mitochondrial disorders are clinically heterogeneous, resulting from nuclear gene and mitochondrial mutations that disturb the mitochondrial functions and dynamics. There is a lack of evidence linking mtDNA mutations to neurodegenerative disorders, mainly due to the absence of noticeable neuropathological lesions in postmortem samples. This review describes various gene mutations in Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis, and stroke. These abnormalities, including PINK1, Parkin, and SOD1 mutations, seem to reveal mitochondrial dysfunctions due to either mtDNA mutation or deletion, the mechanism of which remains unclear in depth.

Keywords: Alzheimer's disease, amyotrophic lateral sclerosis, mtDNA, multiple sclerosis, neurodegeneration, Parkinson's disease, stroke.

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