Generic placeholder image

The Natural Products Journal

Editor-in-Chief

ISSN (Print): 2210-3155
ISSN (Online): 2210-3163

Review Article

Eugenia uniflora L. fruit: A review on its Chemical Composition and Bioactivity

Author(s): Elisa dos Santos pereira, Chirle de Oliveira Raphaelli*, Juliana Rocha Vinholes, Jardel Araújo Ribeiro, Ângela Maria Fiorentini, Leonardo Nora and Márcia Vizzotto

Volume 12, Issue 2, 2022

Published on: 11 January, 2022

Article ID: e070921196205 Pages: 18

DOI: 10.2174/2210315511666210907095136

Price: $65

conference banner
Abstract

The fruits (pitanga) of L. (pitangueira) have pleasant sensory attributes, described as acid, sweet and exotic flavors, and high content of bioactive compounds with antioxidant effects. The botanical characteristics, nutritional, sensory and pharmaceutical properties of leaves and fruits of pitangueira have already been described in several publications, but the information available has never been systematized through a wide literature review such as that carried out in the present study.This study reveals that pitanga is a source of fibers, vitamins A and C, minerals, phenolic compounds and carotenoids. The phenolic compounds myricetin and quercetin, and the carotenoids lycopene, γ-carotene and β-cryptoxanthin are the fruit’s major compounds. Furthermore, in the essential oil of this fruit, compounds beneficial to health, such as oxygenated sesquiterpenes, were found. These compounds, in an in vitro study, were related to the reduction/reversal of damage caused by oxidative stress and inhibition of key enzymes linked to diabetes, dyslipidemia and Alzheimer's. Several studies reveal potential health benefits (antidepressant, anti-inflammatory, antioxidant, analgesic, anti-diabetic, anti-hyperlipidemic, anti-obesity, anti-proliferative and anti-neurodegenerative activities) resulting from bioactive compounds present in the leaf or fruit of the pitangueira. This review shows the promising use of this species for the prevention and control of different diseases and its potential for pharmaceutical and food purposes.

Keywords: Brazilian cherry, health, antioxidant, phenolic compounds, flavonoids, carotenoids.

Graphical Abstract
[1]
Mabberley, DJ Mabberley ’ s plant-book: A portable dictionary of plants, their classification and uses; Wadham college, 2017.
[2]
Gupta, A; Koolwal, N; Dobhal, M Biological importance of phytochemical constituents isolated from genus Eugenia. J. Indian Chem Soc, 2014, 91, 1539-1553.
[3]
Celli, G.B.; Pereira-Netto, A.B.; Beta, T. Comparative analysis of total phenolic content, antioxidant activity, and flavonoids profile of fruits from two varieties of Brazilian cherry (Eugenia uniflora L.) throughout the fruit developmental stages. Food Res. Int., 2011, 44(8), 2442-2451.
[http://dx.doi.org/10.1016/j.foodres.2010.12.036]
[4]
Gomes, R.P. Fruticultura Brasileirath; [4] ed;. São Paulo, 2007.
[5]
Chaieb, K.; Hajlaoui, H.; Zmantar, T.; Kahla-Nakbi, A.B.; Rouabhia, M.; Mahdouani, K.; Bakhrouf, A. The chemical composition and biological activity of clove essential oil, Eugenia caryophyllata (Syzigium aromaticum L. Myrtaceae): a short review. Phytother. Res., 2007, 21(6), 501-506.
[http://dx.doi.org/10.1002/ptr.2124] [PMID: 17380552]
[6]
Filho, G.L.; De Rosso, V.V.; Meireles, M.A.A. Rosa, P.T.V.; Oliveira, A.L.; Mercadante, A.Z.; Cabral, F.A. Supercritical CO2 extraction of carotenoids from pitanga fruits (Eugenia uniflora L.). J. Supercrit. Fluids, 2008, 46(1), 33-39.
[http://dx.doi.org/10.1016/j.supflu.2008.02.014]
[7]
Bezerra, J.E.F.; Júnior, J.S de L.; Júnior, J.F da S. Pitanga Eugenia uniflora, 1st ed; Ministério Meio Ambiente: Brasília, 2018.
[8]
Franzon, R.; Carpenedo, S.; Vinõly, M.D. Raseira, M.C.B. Pitanga (Eugenia uniflora L.). Exot Fruits, 2018, 4, 333-338.
[http://dx.doi.org/10.1016/B978-0-12-803138-4.00044-7]
[9]
Carvalho, P.E.R. Espécies arbóreas brasileiras; 5th [9] ed; rapa InformaçÃo Tecnológica Colombo: Embrapa Florestas: Brasília. , 2006, 2014, .
[10]
Tambara, A.L.; de Los Santos Moraes, L.; Dal Forno, A.H.; Boldori, J.R.; Gonçalves Soares, A.T.; de Freitas Rodrigues, C.; Mariutti, L.R.B.; Mercadante, A.Z.; de Ávila, D.S.; Denardin, C.C. Purple pitanga fruit (Eugenia uniflora L.) protects against oxidative stress and increase the lifespan in Caenorhabditis elegans via the DAF-16/FOXO pathway. Food Chem. Toxicol., 2018, 120, 639-650.
[http://dx.doi.org/10.1016/j.fct.2018.07.057] [PMID: 30077708]
[11]
Ramalho, R.R.F.; Barbosa, J.M.G.; Ferri, P.H.; Santos, S.D.C. Variability of polyphenols and volatiles during fruit development of three pitanga (Eugenia uniflora L.) biotypes. Food Res. Int., 2019, 119, 850-858.
[http://dx.doi.org/10.1016/j.foodres.2018.10.068] [PMID: 30884725]
[12]
Vizzotto, M; Cabral, L; Santos, A. Pitanga (Eugenia uniflora L.).Postharvest Biol Technol Trop Subtrop Fruits; , 2018, 7, p. (5)67.
[13]
dos Santos, A.F.; Silva, S de M.; Alves, R.E. Armazenamento de pitanga sob atmosfera modificada e refrigeraçÃ\poundso: I-transformaçÃ\mues quÃ\-micas em pÃ\textthreesuperiors-colheita. Rev. Bras. Frutic., 2006, 28, 36-41.
[http://dx.doi.org/10.1590/S0100-29452006000100013]
[14]
Cascaes, M.M.; Guilhon, G.M.S.P.; de Aguiar Andrade, E.H.; das Graças Bichara Zoghbi, M.; da Silva Santos, L. das Graças Bichara Zoghbi, M.; da Silva Santos, L.. Constituents and pharmacological activities of Myrcia (Myrtaceae): A review of an aromatic and medicinal group of plants. Int. J. Mol. Sci., 2015, 16(10), 23881-23904.
[http://dx.doi.org/10.3390/ijms161023881] [PMID: 26473832]
[15]
Martelli, F.; Nunes, F. Radicais livres: Em busca do equilíbrio. Cienc. Cult., 2014, 66(3), 54-57.
[http://dx.doi.org/10.21800/S0009-67252014000300017]
[16]
Carocho, M.; Ferreira, I.C.F.R. A review on antioxidants, prooxidants and related controversy: natural and synthetic compounds, screening and analysis methodologies and future perspectives. Food Chem. Toxicol., 2013, 51, 15-25.
[http://dx.doi.org/10.1016/j.fct.2012.09.021] [PMID: 23017782]
[17]
Moura, G.S.; de Oliveira, I.J.; Bonome, L.T da S. Eugenia uniflora L.: potential uses as a bioactive plant. Arq. Inst. Biol. (Sao Paulo), 2018, 85(0), 1-9.
[http://dx.doi.org/10.1590/1808-1657000752017]
[18]
de Souza, A.M.; de Oliveira, C.F.; de Oliveira, V.B.; Betim, F.C.M.; Miguel, O.G.; Miguel, M.D. Traditional uses, phytochemistry, and antimicrobial activities of eugenia species - a review. Planta Med., 2018, 84(17), 1232-1248.
[http://dx.doi.org/10.1055/a-0656-7262] [PMID: 30016828]
[19]
de Lira-Júnior, J.S.; Bezerra, J.E.F.; Lederman, I.E. Liceu.Pitangueira; Recife, 2007, p. 200.
[20]
Onwudiwe, N.; Njokuc, O.; Joshua, P. Phytochemical analysis and acute toxicity/ lethality study of ethanol extract of eugenia uniflora pulp. Res J Pharmacogn Phytochem, 2010, 2, 336-339.
[21]
Onwudiwe, N.N. Evaluation of the nutritional compositions and analgesic effects of the flavonoid fraction of eugenia uniflora ripe fruit pulp. Am J Ethnomedicine, 2018, 5(1), 1-8.
[http://dx.doi.org/10.21767/2348-9502.100007]
[22]
Bagetti, M.; Facco, E.M.P.; Piccolo, J. Hirsch, G.E.; Rodriguez-Amaya, D.; Kobori, C.N.; Vizzotto, M.; Emanuelli, T.. Physicochemical characterization and antioxidant capacity of pitanga fruits (Eugenia uniflora L.). Food Sci. Technol. (Campinas), 2011, 31(1), 147-154.
[http://dx.doi.org/10.1590/S0101-20612011000100021]
[23]
Karwowski, M.; Masson, M.; Lenzi, M. Scheer, A.; Haminiuk, C.. Characterization of tropical fruits: Rheology, stability and phenolic compounds. Acta Aliment., 2013, 42(4), 586-598.
[http://dx.doi.org/10.1556/AAlim.42.2013.4.13]
[24]
Filippi, D.; Bilibio, D.; Bender, J.P. Carniel, N.; Priamo, W.L.. Kinetic extraction of total polyphenols from pitanga (Eugenia Uniflora L.): Effect of ultrasonic treatment, modeling and antioxidant potential. J. Food Process Eng., 2015, 38(4), 320-328.
[http://dx.doi.org/10.1111/jfpe.12135]
[25]
Rodrigues, A.C.; Zola, F.G.; Ávila Oliveira, B.; Sacramento, N.T.; da Silva, E.R.; Bertoldi, M.C.; Taylor, J.G.; Pinto, U.M. Quorum quenching and microbial control through phenolic extract of eugenia uniflora fruits. J. Food Sci., 2016, 81(10), M2538-M2544.
[http://dx.doi.org/10.1111/1750-3841.13431] [PMID: 27603708]
[26]
Migues, I.; Baenas, N.; Gironés-Vilaplana, A.; Cesio, M.V.; Heinzen, H.; Moreno, D.A. Phenolic profiling and antioxidant capacity of Eugenia uniflora L. (Pitanga) samples collected in different uruguayan locations. Foods, 2018, 7(5), 1-12.
[http://dx.doi.org/10.3390/foods7050067] [PMID: 29695116]
[27]
Freyre, M.R.; Baigorria, C.M.; Rozycki, V.R.; Bernardi, C.M.; Charpentier, M. Vegetales silvestres sub explotados del Chaco argentino y su potencial como recurso alimenticio. Arch. Latinoam. Nutr., 2000, 50(4), 394-399.
[PMID: 11464672]
[28]
Brazilian food composition table, 4th ed; Nepa – Núcleo de Estudos e pesquisas em AlimentaçÃo>University of Campinas U.,, 2020.
[29]
Franzon, R.C.; Carpenedo, S.; Viñoly, M.D. Pitanga— Eugenia uniflora L.Exotc Fruits; , 2018, pp. 333-338.
[http://dx.doi.org/10.1016/B978-0-12-803138-4.00044-7]
[30]
Lee, S.M.; Han, H.W.; Yim, S.Y. Beneficial effects of soy milk and fiber on high cholesterol diet-induced alteration of gut microbiota and inflammatory gene expression in rats. Food Funct., 2015, 6(2), 492-500.
[http://dx.doi.org/10.1039/C4FO00731J] [PMID: 25477035]
[31]
Brownawell, A.M.; Caers, W.; Gibson, G.R.; Kendall, C.W.; Lewis, K.D.; Ringel, Y.; Slavin, J.L. Prebiotics and the health benefits of fiber: current regulatory status, future research, and goals. J. Nutr., 2012, 142(5), 962-974.
[http://dx.doi.org/10.3945/jn.112.158147] [PMID: 22457389]
[32]
Feliciano, R.P.; Antunes, C.; Ramos, A. Serra, A.T.; Figueira, M.E.; Duarte, C.M.M.; Carvalho, A.; Bronze, M.R. Characterization of traditional and exotic apple varieties from Portugal. Part 1 – Nutritional, phytochemical and sensory evaluation. J. Funct. Foods, 2010, 2(1), 35-45.
[http://dx.doi.org/10.1016/j.jff.2009.12.004]
[33]
Denardin, C.C.; Hirsch, G.E.; da Rocha, R.F.; Vizzotto, M.; Henriques, A.T.; Moreira, J.C.F.; Guma, F.T.C.R.; Emanuelli, T. Antioxidant capacity and bioactive compounds of four Brazilian native fruits. J. Food Drug Anal., 2015, 23(3), 387-398.
[http://dx.doi.org/10.1016/j.jfda.2015.01.006] [PMID: 28911695]
[34]
Grosso, G.; Bei, R.; Mistretta, A.; Marventano, S.; Calabrese, G.; Masuelli, L.; Giganti, M.G.; Modesti, A.; Galvano, F.; Gazzolo, D. Effects of vitamin C on health: a review of evidence. Front. Biosci., 2013, 18(3), 1017-1029.
[http://dx.doi.org/10.2741/4160] [PMID: 23747864]
[35]
Bicas, J.L.; Molina, G.; Dionísio, A.P. Barros, F.F.C.; Wagner,R.; Maróstica, M.R., Jr; Pastore, G.M.. Volatile constituents of exotic fruits from Brazil. Food Res. Int., 2011, 44(7), 1843-1855.
[http://dx.doi.org/10.1016/j.foodres.2011.01.012]
[36]
Elshafie, H.S.; Camele, I. An overview of the biological effects of some mediterranean essential oils on human health. BioMed Res. Int., 2017, 2017, 9268468.
[http://dx.doi.org/10.1155/2017/9268468] [PMID: 29230418]
[37]
Shaaban, H.A.E.; El-Ghorab, A.H.; Shibamoto, T. Bioactivity of essential oils and their volatile aroma components. J. Essent. Oil Res., 2012, 24, 203-212. [Review].
[http://dx.doi.org/10.1080/10412905.2012.659528]
[38]
Wolffenbuttel, A.N.; Zamboni, A.; dos Santos, M.K. Chemical components of citrus essential oils from Brazil. Nat. Prod. J., 2015, 5(1), 14-27.
[http://dx.doi.org/10.2174/221031550501150414095331]
[39]
Santos Silva, J.; Damiani, C.; da Cunha, M.C. Nunes Carvalho, E.E.; de Barros Vilas Boas, E.V.. Volatile profiling of pitanga fruit (Eugenia uniflora L.) at different ripening stages using solid-phase microextraction and mass spectrometry coupled with gas chromatography. Sci. Hortic. (Amsterdam), 2019, 250, 366-370.
[http://dx.doi.org/10.1016/j.scienta.2019.02.076]
[40]
Josino Soares, D.; Pignitter, M.; Ehrnhöfer-Ressler, M.M.; Walker, J.; Montenegro Brasil, I.; Somoza, V. Identification and quantification of oxidoselina-1,3,7(11)-trien-8-one and cyanidin-3-glucoside as one of the major volatile and non-volatile low-molecular-weight constituents in pitanga pulp. PLoS One, 2015, 10(9), e0138809.
[http://dx.doi.org/10.1371/journal.pone.0138809] [PMID: 26394146]
[41]
Malaman, F.S.; Moraes, L.A.B.; West, C. Ferreira, N.J.; Oliveira, A.L.. Supercritical fluid extracts from the Brazilian cherry (Eugenia uniflora L.): Relationship between the extracted compounds and the characteristic flavour intensity of the fruit. Food Chem., 2011, 124(1), 85-92.
[http://dx.doi.org/10.1016/j.foodchem.2010.05.109]
[42]
Garmus, T.T.; Paviani, L.C.; Queiroga, C.L. ; Magalhães, P.M.; Cabral, F.A.. Extraction of phenolic compounds from pitanga (Eugenia uniflora L.) leaves by sequential extraction in fixed bed extractor using supercritical CO2, ethanol and water as solvents. J. Supercrit. Fluids, 2014, 86, 4-14.
[http://dx.doi.org/10.1016/j.supflu.2013.11.014]
[43]
Paganga, G.; Miller, N.; Rice-Evans, C.A. The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute? Free Radic. Res., 1999, 30(2), 153-162.
[http://dx.doi.org/10.1080/10715769900300161] [PMID: 10193583]
[44]
Rechner, A.R.; Kuhnle, G.; Bremner, P.; Hubbard, G.P.; Moore, K.P.; Rice-Evans, C.A. The metabolic fate of dietary polyphenols in humans. Free Radic. Biol. Med., 2002, 33(2), 220-235.
[http://dx.doi.org/10.1016/S0891-5849(02)00877-8] [PMID: 12106818]
[45]
Vinholes, J.; Lemos, G.; Lia Barbieri, R. Franzon, R.C.; Vizzotto, M. In vitro assessment of the antihyperglycemic and antioxidant properties of araçá, butiá and pitanga. Food Biosci., 2017, 19, 92-100.
[http://dx.doi.org/10.1016/j.fbio.2017.06.005]
[46]
Chaves, V.C.; Boff, L.; Vizzotto, M.; Calvete, E.; Reginatto, F.H.; Simões, C.M. Berries grown in Brazil: anthocyanin profiles and biological properties. J. Sci. Food Agric., 2018, 98(11), 4331-4338.
[http://dx.doi.org/10.1002/jsfa.8959] [PMID: 29430645]
[47]
Haminiuk, C.W.I.; Plata-Oviedo, M.S.V.; Guedes, A.R. Stafussa,A.P.; Bona, E.; Carpes, S.T.. Chemical, antioxidant and antibacterial study of Brazilian fruits. Int. J. Food Sci. Technol., 2011, 46(7), 1529-1537.
[http://dx.doi.org/10.1111/j.1365-2621.2011.02653.x]
[48]
Jacques, A.C.; Pertuzatti, P.B.; Barcia, M.T. Scientific note: Bioactive compounds in small fruits cultivated in the southern region of Brazil. Braz. J. Food. Technol., 2009, 12(1), 123-127.
[http://dx.doi.org/10.4260/BJFT20094608]
[49]
You, Q.; Wang, B.; Chen, F. Huang, Z.; Wang, X.; Luo, P.G. Comparison of anthocyanins and phenolics in organically and conventionally grown blueberries in selected cultivars. Food Chem., 2011, 125(1), 201-208.
[http://dx.doi.org/10.1016/j.foodchem.2010.08.063]
[50]
Hoffmann-Ribani, R.; Huber, L.S.; Rodriguez-Amaya, D.B. Flavonols in fresh and processed Brazilian fruits. J. Food Compos. Anal., 2009, 22(4), 263-268.
[http://dx.doi.org/10.1016/j.jfca.2008.12.004]
[51]
Oliveira, A.L.; Destandau, E.; Fougère, L.; Lafosse, M. Isolation by pressurised fluid extraction (PFE) and identification using CPC and HPLC/ESI/MS of phenolic compounds from Brazilian cherry seeds (Eugenia uniflora L.). Food Chem., 2014, 145, 522-529.
[http://dx.doi.org/10.1016/j.foodchem.2013.08.065] [PMID: 24128509]
[52]
Santos, DN e. Study of supercritical extraction from Brazilian cherry seeds (Eugenia uniflora L.) with bioactive compounds. Food Bioprod. Process., 2014, 94, 365-374.
[53]
Ribeiro da Silva, L.M.; Teixeira de Figueiredo, E.A.; Silva Ricardo, N.M.; Pinto Vieira, I.G.; Wilane de Figueiredo, R.; Brasil, I.M.; Gomes, C.L. Quantification of bioactive compounds in pulps and by-products of tropical fruits from Brazil. Food Chem., 2014, 143, 398-404.
[http://dx.doi.org/10.1016/j.foodchem.2013.08.001] [PMID: 24054258]
[54]
Porcu, O.M.; Rodriguez-Amaya, D.B. Variation in the carotenoid composition of the lycopene-rich Brazilian fruit Eugenia uniflora L. Plant Foods Hum. Nutr., 2008, 63(4), 195-199.
[http://dx.doi.org/10.1007/s11130-008-0085-9] [PMID: 18679799]
[55]
Cavalcante, M.L.; Rodriguez-amaya, D.B. Carotenoid composition of the tropical fruits Eugenia uniflora and Malpighia glabra. Dev Food Sci, 1992, 29, 643-650.
[http://dx.doi.org/10.1016/B978-0-444-88834-1.50058-2]
[56]
Azevedo-Meleiro, C.H.; Rodriguez-Amaya, D.B. Confirmation of the identity of the carotenoids of tropical fruits by HPLC-DAD and HPLC-MS. J. Food Compos. Anal., 2004, 17(3-4), 385-396.
[http://dx.doi.org/10.1016/j.jfca.2004.02.004]
[57]
Seifried, H.E.; Anderson, D.E.; Fisher, E.I.; Milner, J.A. A review of the interaction among dietary antioxidants and reactive oxygen species. J. Nutr. Biochem., 2007, 18(9), 567-579.
[http://dx.doi.org/10.1016/j.jnutbio.2006.10.007] [PMID: 17360173]
[58]
Birben, E.; Sahiner, U.M.; Sackesen, C.; Erzurum, S.; Kalayci, O. Oxidative stress and antioxidant defense. World Allergy Organ. J., 2012, 5(1), 9-19.
[http://dx.doi.org/10.1097/WOX.0b013e3182439613] [PMID: 23268465]
[59]
Dexheimer, G.M.; Pozzobon, A. Biological activity of plants from the Myrtaceae family: A systematic review of papers published from 1989 to 2015. Rev. Cuba. Plantas Med., 2017, 22, 1-22.
[60]
Leonarduzzi, G.; Sottero, B.; Poli, G. Targeting tissue oxidative damage by means of cell signaling modulators: the antioxidant concept revisited. Pharmacol. Ther., 2010, 128(2), 336-374.
[http://dx.doi.org/10.1016/j.pharmthera.2010.08.003] [PMID: 20732353]
[61]
Svilar, D.; Goellner, E.M.; Almeida, K.H.; Sobol, R.W. Base excision repair and lesion-dependent subpathways for repair of oxidative DNA damage. Antioxid. Redox Signal., 2011, 14(12), 2491-2507.
[http://dx.doi.org/10.1089/ars.2010.3466] [PMID: 20649466]
[62]
Lobo, V.; Patil, A.; Phatak, A.; Chandra, N. Free radicals, antioxidants and functional foods: Impact on human health. Pharmacogn. Rev., 2010, 4(8), 118-126.
[http://dx.doi.org/10.4103/0973-7847.70902] [PMID: 22228951]
[63]
da Cunha, F.A.B.; Waczuk, E.P.; Duarte, A.E.; Barros, L.M.; Elekofehinti, O.O.; Matias, E.F.F.; da Costa, J.G.M.; Sanmi, A.A.; Boligon, A.A.; da Rocha, J.B.T.; Souza, D.O.; Posser, T.; Coutinho, H.D.M.; Franco, J.L.; Kamdem, J.P. Cytotoxic and antioxidative potentials of ethanolic extract of Eugenia uniflora L. (Myrtaceae) leaves on human blood cells. Biomed. Pharmacother., 2016, 84, 614-621.
[http://dx.doi.org/10.1016/j.biopha.2016.09.089] [PMID: 27694006]
[64]
Vega-Galvez, A.; Rodríguez, A.; Stucken, K. antioxidant, functional properties and health-promoting potential of native South American berries: a review. J. Sci. Food Agric., 2021, 101(2), 364-378. Epub ahead of print
[http://dx.doi.org/10.1002/jsfa.10621] [PMID: 32608511]
[65]
Dikpınar, T.; Süzgeç-Selçuk, S. Antimicrobial activities of medicinal plants containing phenolic compounds. Nat. Prod. J., 2019, 10(5), 514-534.
[http://dx.doi.org/10.2174/2210315510666191227150222]
[66]
Correia, R.T.; Borges, K.C.; Medeiros, M.F.; Genovese, M.I. Bioactive compounds and phenolic-linked functionality of powdered tropical fruit residues. Food Sci. Technol. Int., 2012, 18(6), 539-547.
[http://dx.doi.org/10.1177/1082013211433077] [PMID: 23014856]
[67]
Massarioli, A.P.; Oldoni, T.L.C.; Moreno, I.A.M. Antioxidant activity of different pitanga (Eugenia uniflora L. ) fruit fractions. J. Food Agric. Environ., 2013, 11, 288-293.
[68]
Josino Soares, D.; Walker, J.; Pignitter, M.; Walker, J.M.; Imboeck, J.M.; Ehrnhoefer-Ressler, M.M.; Montenegro Brasil, I.; Somoza, V. Pitanga (Eugenia uniflora L.) fruit juice and two major constituents thereof exhibit anti-inflammatory properties in human gingival and oral gum epithelial cells. Food Funct., 2014, 5(11), 2981-2988.
[http://dx.doi.org/10.1039/C4FO00509K] [PMID: 25228206]
[69]
Figueirôa, E.O.; Nascimento da Silva, L.C.; de Melo, C.M.; Neves, J.K.; da Silva, N.H.; Pereira, V.R.; Correia, M.T. Evaluation of antioxidant, immunomodulatory, and cytotoxic action of fractions from Eugenia uniflora L. and Eugenia malaccensis L.: correlation with polyphenol and flavanoid content. ScientificWorldJournal, 2013, 2013, 125027.
[http://dx.doi.org/10.1155/2013/125027] [PMID: 24089599]
[70]
Clement, M.V.; Luo, L. organismal aging and oxidants beyond macromolecules damage. Proteomics, 2020, 20(5-6), e1800400.
[http://dx.doi.org/10.1002/pmic.201800400] [PMID: 31743593]
[71]
Tissenbaum, H.A. DAF-16: FOXO in the Context of C. elegans. Curr. Top. Dev. Biol., 2018, 127, 1-21.
[http://dx.doi.org/10.1016/bs.ctdb.2017.11.007] [PMID: 29433733]
[72]
Hanhineva, K.; Törrönen, R.; Bondia-Pons, I.; Pekkinen, J.; Kolehmainen, M.; Mykkänen, H.; Poutanen, K. Impact of dietary polyphenols on carbohydrate metabolism. Int. J. Mol. Sci., 2010, 11(4), 1365-1402.
[http://dx.doi.org/10.3390/ijms11041365] [PMID: 20480025]
[73]
Oliveira, P.S.; Chaves, V.C.; Bona, N.P.; Soares, M.S.P.; Cardoso, J.S.; Vasconcellos, F.A.; Tavares, R.G.; Vizzotto, M.; Silva, L.M.C.D.; Grecco, F.B.; Gamaro, G.D.; Spanevello, R.M.; Lencina, C.L.; Reginatto, F.H.; Stefanello, F.M. Eugenia uniflora fruit (red type) standardized extract: a potential pharmacological tool to diet-induced metabolic syndrome damage management. Biomed. Pharmacother., 2017, 92, 935-941.
[http://dx.doi.org/10.1016/j.biopha.2017.05.131] [PMID: 28618655]
[74]
Borges, K.; Bezerra, M.; Rocha, M. fresh and spray dried pitanga (eugenia uniflora) and jambolan (syzygium cumini) pulps are natural sources of bioactive compounds with functional attributes. J. Probiotics Health, 2016, 04(2)e1000145 Epub ahead of print
[http://dx.doi.org/10.4172/2329-8901.1000145]
[75]
Tadera, K.; Minami, Y.; Takamatsu, K.; Matsuoka, T. Inhibition of α-glucosidase and α-amylase by flavonoids. J. Nutr. Sci. Vitaminol. (Tokyo), 2006, 52(2), 149-153.
[http://dx.doi.org/10.3177/jnsv.52.149] [PMID: 16802696]
[76]
Vinholes, J.; Reis, S.F.; Lemos, G.; Barbieri, R.L.; de Freitas, V.; Franzon, R.C.; Vizzotto, M. Effect of in vitro digestion on the functional properties of Psidium cattleianum Sabine (araçá), Butia odorata (Barb. Rodr.) Noblick (butiá) and Eugenia uniflora L. (pitanga) fruit extracts. Food Funct., 2018, 9(12), 6380-6390.
[http://dx.doi.org/10.1039/C8FO01329B] [PMID: 30457133]
[77]
de Oliveira Raphaelli, C.; Dos Santos Pereira, E.; Camargo, T.M.; Vinholes, J.; Rombaldi, C.V.; Vizzotto, M.; Nora, L. apple phenolic extracts strongly inhibit α-glucosidase activity. Plant Foods Hum. Nutr., 2019, 74(3), 430-435.
[http://dx.doi.org/10.1007/s11130-019-00757-3] [PMID: 31302831]
[78]
Kang, Y.E.; Kim, J.M.; Joung, K.H.; Lee, J.H.; You, B.R.; Choi, M.J.; Ryu, M.J.; Ko, Y.B.; Lee, M.A.; Lee, J.; Ku, B.J.; Shong, M.; Lee, K.H.; Kim, H.J. The roles of adipokines, proinflammatory cytokines, and adipose tissue macrophages in obesity-associated insulin resistance in Modest Obesity and Early Metabolic Dysfunction. PLoS One, 2016, 11(4), e0154003.
[http://dx.doi.org/10.1371/journal.pone.0154003] [PMID: 27101398]
[79]
de Souza Cardoso, J.; Oliveira, P.S.; Bona, N.P.; Vasconcellos, F.A.; Baldissarelli, J.; Vizzotto, M.; Soares, M.S.P.; Ramos, V.P.; Spanevello, R.M.; Lencina, C.L.; Tavares, R.G.; Stefanello, F.M. Antioxidant, antihyperglycemic, and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance. Redox Rep., 2018, 23(1), 41-46.
[http://dx.doi.org/10.1080/13510002.2017.1375709] [PMID: 29088999]
[80]
Roncato, J.F.F.; Camara, D.; Brussulo Pereira, T.C.; Quines, C.B.; Colomé, L.M.; Denardin, C.; Haas, S.; Ávila, D.S. Lipid reducing potential of liposomes loaded with ethanolic extract of purple pitanga (Eugenia uniflora) administered to Caenorhabditis elegans. J. Liposome Res., 2019, 29(3), 274-282.
[http://dx.doi.org/10.1080/08982104.2018.1552705] [PMID: 30563398]
[81]
Oliveira, P.S.; Soares, M.S.P.; Bona, N.P.; da Silva, P.G.; Mendonça, L.T.; Vieira, A.; Dal-Pizzol, F.; Vizzotto, M.; Lencina, C.L.; Spanevello, R.M.; Stefanello, F.M. Brazilian native fruit extracts act as preventive agents modulating the purinergic and cholinergic signalling in blood cells and serum in a rat model of metabolic syndrome. Arch. Physiol. Biochem., 2020, 1-8.
[http://dx.doi.org/10.1080/13813455.2020.1743723] [PMID: 32212985]
[82]
Guo, R.; Chang, X.; Guo, X.; Brennan, C.S.; Li, T.; Fu, X.; Liu, R.H. Phenolic compounds, antioxidant activity, antiproliferative activity and bioaccessibility of Sea buckthorn (Hippophaë rhamnoides L.) berries as affected by in vitro digestion. Food Funct., 2017, 8(11), 4229-4240.
[http://dx.doi.org/10.1039/C7FO00917H] [PMID: 29046908]
[83]
Wang, E.; Liu, Y.; Xu, C.; Liu, J. Antiproliferative and proapoptotic activities of anthocyanin and anthocyanidin extracts from blueberry fruits on B16-F10 melanoma cells. Food Nutr. Res., 2017, 61(1), 1325308.
[http://dx.doi.org/10.1080/16546628.2017.1325308] [PMID: 28680383]
[84]
Takeshima, M.; Ono, M.; Higuchi, T.; Chen, C.; Hara, T.; Nakano, S. Anti-proliferative and apoptosis-inducing activity of lycopene against three subtypes of human breast cancer cell lines. Cancer Sci., 2014, 105(3), 252-257.
[http://dx.doi.org/10.1111/cas.12349] [PMID: 24397737]
[85]
Denardin, C.C.; Parisi, M.M.; Martins, L.A.M.; Terra, S.R.; Borojevic, R.; Vizzotto, M.; Perry, M.L.; Emanuelli, T.; Guma, F.T. Antiproliferative and cytotoxic effects of purple pitanga (Eugenia uniflora L.) extract on activated hepatic stellate cells. Cell Biochem. Funct., 2014, 32(1), 16-23.
[http://dx.doi.org/10.1002/cbf.2965] [PMID: 23475531]
[86]
Denardin, C.C.; Martins, L.A.M.; Parisi, M.M.; Vieira, M.Q.; Terra, S.R.; Barbé-Tuana, F.M.; Borojevic, R.; Vizzotto, M.; Emanuelli, T.; Guma, F.C. Autophagy induced by purple pitanga (Eugenia uniflora L.) extract triggered a cooperative effect on inducing the hepatic stellate cell death. Cell Biol. Toxicol., 2017, 33(2), 197-206.
[http://dx.doi.org/10.1007/s10565-016-9366-5] [PMID: 27744523]
[87]
Wang, J.; Wu, X.; Lai, W.; Long, E.; Zhang, X.; Li, W.; Zhu, Y.; Chen, C.; Zhong, X.; Liu, Z.; Wang, D.; Lin, H. Prevalence of depression and depressive symptoms among outpatients: a systematic review and meta-analysis. BMJ Open, 2017, 7(8), e017173.
[http://dx.doi.org/10.1136/bmjopen-2017-017173] [PMID: 28838903]
[88]
Bishwajit, G.; O’Leary, D.P.; Ghosh, S.; Sanni, Y.; Shangfeng, T.; Zhanchun, F. Association between depression and fruit and vegetable consumption among adults in South Asia. BMC Psychiatry, 2017, 17(1), 15.
[http://dx.doi.org/10.1186/s12888-017-1198-1] [PMID: 28088202]
[89]
Bonilla-Jaime, H.; Guadarrama-Cruz, G.; Alarcon-Aguilar, F.J.; Limón-Morales, O.; Vazquez-Palacios, G. Antidepressant-like activity of Tagetes lucida Cav. is mediated by 5-HT(1A) and 5-HT(2A) receptors. J. Nat. Med., 2015, 69(4), 463-470.
[http://dx.doi.org/10.1007/s11418-015-0909-5] [PMID: 26062718]
[90]
Ma, Z.; Wang, G.; Cui, L.; Wang, Q. Myricetin attenuates depressant-like behavior in mice subjected to repeated restraint stress. Int. J. Mol. Sci., 2015, 16(12), 28377-28385.
[http://dx.doi.org/10.3390/ijms161226102] [PMID: 26633366]
[91]
Shin, J.C.; Jung, H.Y.; Harikishore, A.; Kwon, O.D.; Yoon, H.S.; Kim, K.T.; Choi, B.H. The flavonoid myricetin reduces nocturnal melatonin levels in the blood through the inhibition of serotonin N-acetyltransferase. Biochem. Biophys. Res. Commun., 2013, 440(2), 312-316.
[http://dx.doi.org/10.1016/j.bbrc.2013.09.076] [PMID: 24076393]
[92]
Semwal, D.K.; Semwal, R.B.; Combrinck, S.; Viljoen, A. Myricetin: A dietary molecule with diverse biological activities. Nutrients, 2016, 8(2), 90.
[http://dx.doi.org/10.3390/nu8020090] [PMID: 26891321]
[93]
de Andrade-Teles, R.B.; Diniz, T.C.; Costa Pinto, T.C. de Oliveira Júnior, R.G.; Gama E Silva, M.; de Lavor, É.M.; Fernandes, A.W.C.; de Oliveira, A.P.; de Almeida Ribeiro, F.P.R.; da Silva, A.A.M.; Cavalcante, T.C.F.; Quintans Júnior, L.J.; da Silva Almeida, J.R.G. Flavonoids as therapeutic agents in Alzheimer’s and Parkinson’s diseases: A systematic review of preclinical evidences. Oxid. Med. Cell. Longev., 2018, 2018, 7043213.
[http://dx.doi.org/10.1155/2018/7043213] [PMID: 29861833]
[94]
Subash, S.; Essa, M.M.; Al-Adawi, S.; Memon, M.A.; Manivasagam, T.; Akbar, M. Neuroprotective effects of berry fruits on neurodegenerative diseases. Neural Regen. Res., 2014, 9(16), 1557-1566.
[http://dx.doi.org/10.4103/1673-5374.139483] [PMID: 25317174]
[95]
Figueira, I.; Menezes, R.; Macedo, D.; Costa, I.; Dos Santos, C.N. polyphenols beyond barriers: A glimpse into the brain. Curr. Neuropharmacol., 2017, 15(4), 562-594.
[http://dx.doi.org/10.2174/1570159X14666161026151545] [PMID: 27784225]
[96]
Omena, C.M.B.; Valentim, I.B.; Guedes, G da S. Rabelo, L.A.; Mano, C.M.; Bechara, E.J.H.; Sawaya, A.C.H.F.; Trevisan, M.T.S.; da Costa, J.G.; Ferreira, R.C.S.; Sant’Ana, A.E.G.; Goulart, M.O.F.. Antioxidant, anti-acetylcholinesterase and cytotoxic activities of ethanol extracts of peel, pulp and seeds of exotic Brazilian fruits: Antioxidant, anti-acetylcholinesterase and cytotoxic activities in fruits. Food Res. Int., 2012, 49(1), 334-344.
[http://dx.doi.org/10.1016/j.foodres.2012.07.010]
[97]
Siebert, D.A.; de Mello, F.; Alberton, M.D. Determination of acetylcholinesterase and α-glucosidase inhibition by electrophoretically-mediated microanalysis and phenolic profile by HPLC-ESI-MS/MS of fruit juices from Brazilian Myrtaceae Plinia cauliflora (Mart.) Kausel and Eugenia uniflora L. Nat. Prod. Res., 2018, 0, 1-6.
[PMID: 30618311]
[98]
Kim, J.H.; Choi, G.N.; Kwak, J.H. Jeong, H.R.; Jeong, C-H.; Heo, H.J.. neuronal cell Protection and acetylcholinesterase inhibitory effect of the phenolics in chestnut inner skin. Food Sci. Biotechnol., 2011, 20(2), 311-312.
[http://dx.doi.org/10.1007/s10068-011-0044-3]
[99]
Lopes, A.S.; Mattietto, R.D.A.; de Menezes, H.C. Rheological behavior of Brazilian Cherry (Eugenia uniflora L.) pulp at pasteurization temperatures. Food Sci Technol (Campinas), 2013, 33(1), 26-31.
[http://dx.doi.org/10.1590/S0101-20612013005000001]
[100]
de Oliveira, A.L.; de Almeida, E.; da Silva, F.B.R. Elemental contents in exotic Brazilian tropical fruits evaluated by energy dispersive X-ray fluorescence. Sci. Agric., 2006, 63(1), 82-84.
[http://dx.doi.org/10.1590/S0103-90162006000100013]
[101]
Meinhart, A.D.; Damin, F.M.; Caldeirão, L.; de Jesus Filho, M.; da Silva, L.C.; da Silva Constant, L.; Filho, J.T.; Wagner, R.; Godoy, H.T. Chlorogenic and caffeic acids in 64 fruits consumed in Brazil. Food Chem., 2019, 286, 51-63.
[http://dx.doi.org/10.1016/j.foodchem.2019.02.004] [PMID: 30827640]
[102]
Rutz, J.K.; Zambiazi, R.C.; Borges, C.D.; Krumreich, F.D.; da Luz, S.R.; Hartwig, N.; da Rosa, C.G. Microencapsulation of purple Brazilian cherry juice in xanthan, tara gums and xanthan-tara hydrogel matrixes. Carbohydr. Polym., 2013, 98(2), 1256-1265.
[http://dx.doi.org/10.1016/j.carbpol.2013.07.058] [PMID: 24053801]
[103]
de Araújo, F.F.; Neri-Numa, I.A.; de Paulo Farias, D.; da Cunha, G.R.M.C.; Pastore, G.M. Wild Brazilian species of Eugenia genera (Myrtaceae) as an innovation hotspot for food and pharmacological purposes. Food Res. Int., 2019, 121, 57-72.
[http://dx.doi.org/10.1016/j.foodres.2019.03.018] [PMID: 31108783]
[104]
Asif, M. Bioactive phytochemical constituents of some edible fruits of Myrtaceae family. Am J Nutr Res, 2014, 1, 1-17.
[105]
Einbond, L.S.; Reynertson, K.A.; Luo, X.D. Basile, M.J.; Kennelly,E.J.. Anthocyanin antioxidants from edible fruits. Food Chem., 2004, 84(1), 23-28.
[http://dx.doi.org/10.1016/S0308-8146(03)00162-6]
[106]
Biazotto, K.R.; de Souza Mesquita, L.M.; Neves, B.V.; Braga, A.R.C.; Tangerina, M.M.P.; Vilegas, W.; Mercadante, A.Z.; De Rosso, V.V. brazilian biodiversity fruits: discovering bioactive compounds from underexplored sources. J. Agric. Food Chem., 2019, 67(7), 1860-1876.
[http://dx.doi.org/10.1021/acs.jafc.8b05815] [PMID: 30707576]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy