Title:In-vitro Evaluation of Isatin Derivatives as Potent Anti-Breast Cancer Agents against
MCF-7, MDA MB 231, MDA-MB 435 and MDA-MB 468 Breast Cancers Cell Lines:
A Review
Volume: 22
Issue: 10
Author(s): Garima Chauhan*, Dharam Pal Pathak, Faraat Ali, Pragya Dubey and Shaik Khasimbi
Affiliation:
- Department of Pharmaceutical Chemistry, Delhi Institute of Pharmaceutical Sciences and Research, Mehrauli-Badarpur Road, Sector 3, Pushp Vihar, New Delhi, Delhi 110017, India
Keywords:
Breast cancer, IST, anti-BC agents, cell lines, structure-activity relationship, toxicity.
Abstract:
Introduction: Breast cancer (BC) is one of the most frequent malignancies and the most common reasons
for impermanence in women. The backbone of therapy for BC is principally chemotherapy, but its non-specific nature
to differentiate between normal cells and cancer cells and severe side effects are the main barriers in its use. So, there is
an intense requirement to enlarge more efficacious, more specific and safer anti-BC agents.
Objective: Isatin (IST) is an endogenous molecule that is a principal class of heterocyclic compounds and exhibits a
wide range of therapeutic activities which can be used as a starting material for the synthesis of several drug molecules.
Many kinds of literature were reported previously on different pharmacological activities of IST derivatives and particularly
on anticancer activity but this review mainly focuses on anti-BC activities of IST derivatives through MCF-7,
MDA MB 231, MDA-MB 435 and MDA-MB 468 cell lines. Herein we mentioned; a total of 33 IST derivatives (compound
24- 56) which show good anti-BC activity. IST-derived compounds are also available in the market and are
used for various cancer types like sunitinib for renal cell carcinoma (RCC) and Nintedanib for the cryptogenic fibrosing
alveolitis treatment, but when evaluated for BC, they did not prove to be much successful.
Conclusion: This review mainly highlights anti-BC activities of various IST analogues using MCF-7, MDA MB 231,
MDA-MB 435 and MDA-MB 468 cell lines, displaying the potent compound of the series and structure-activity relationships
of compounds with molecular docking also. So, this study mainly shows the importance of IST as a major
source for drug design and development of newer anti-BC drugs.