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Review Article

新型羧酸生物异构体实际应用的最新进展

卷 29, 期 13, 2022

发表于: 03 January, 2022

页: [2203 - 2234] 页: 32

弟呕挨: 10.2174/0929867328666210820112126

价格: $65

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摘要

背景：羧酸部分是一个重要的官能团，在约450种药物的药效团中具有特征。不幸的是，由于不可预见的毒性问题，一些含羧酸的药物已退出市场。与羧酸盐部分相关的其他问题包括代谢稳定性降低或生物膜上的被动扩散有限。药物化学家经常转向生物异构体来规避这些障碍。 目的：综述2013年以来文献中出现的新型羧酸生物异构体的各种应用。 结果：我们总结了羧酸生物异甾性的最新进展。特别是，我们专注于这些取代物带来的生物活性，选择性或物理化学性质的变化，以及每种异甾体的优缺点。 结论：本文讨论的主题强调了对羧酸盐生物异构体的持续兴趣。新型羧酸替代品的开发显示出改进的药理学特征，这证明了克服现代药物设计中面临的挑战所需的创新和创造力。

关键词: 异甾体，生物异甾性，羧酸，药物设计，酸度，亲脂性。

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