Title:Critical Functions of lncRNA DGCR5 in Cancers of the Digestive System
Volume: 27
Issue: 40
Author(s): Chengyu Hu, Wen Xu, Bei Wang, Jinlan Chen, Zixian Zhou, Gang Zhou*Chengfu Yuan*
Affiliation:
- College of Traditional Chinese Medicine, China Three Gorges University, Yichang 443002,China
- College of Medical Science, China Three Gorges University, Yichang 443002,China
Keywords:
Long non-coding RNA, DGCR5, digestive system cancer, molecular mechanisms, treatment, therapeutic target.
Abstract:
Background: Long non-coding RNAs (lncRNAs) has no protein-coding potential due to the lack of
an apparent open reading frame. There is growing evidence that lncRNA DGCR5 has a vital regulatory role in
human illnesses' pathological development, particularly in the digestive system's carcinogenesis and progression.
Abnormal DGCR5 expression affects different cellular functions such as proliferation, aggression, and
metastasis. This paper aims to probe into the pathophysiological functions and molecular mechanisms of
DGCR5 in cancers of the digestive system.
Methods: This review summarizes and analyzes the biological functions and mechanisms of lncRNA DGCR5
in digestive system cancers occurrence. Relevant studies were conducted and reviewed by searching PubMed
for articles with lncRNA DGCR5 and digestive system cancer as keywords in recent years.
Results: DCGR5, as a novel tumor-related lncRNA, is recently identified to be abnormally expressed in digestive
system cancers, such as pancreatic ductal adenocarcinoma, pancreatic cancer, gastric cancer, gallbladder
cancer, colorectal cancer, and hepatocellular carcinoma. The role played by DCGR5 is vital and varies in different
digestive cancers. Taken together, aberrant expression of DCGR5 regulates the progression of digestive
cancers by affecting cancer cell proliferation, aggression, metastasis, and drug resistance.
Conclusion: LncRNA DGCR5 might be a viable marker or a promising therapeutic target in digestive system
cancers.
