Title:Progression in Moyamoya Disease: Clinical Features, Neuroimaging
Evaluation, and Treatment
Volume: 20
Issue: 2
Author(s): Xin Zhang *, Weiping Xiao*, Qing Zhang, Ding Xia, Peng Gao , Jiabin Su, Heng Yang , Xinjie Gao, Wei Ni, Yu Lei*Yuxiang Gu*
Affiliation:
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Neurosurgical Institute of Fudan University, Shanghai, China
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Department of Neurosurgery, Huashan Hospital North, Fudan University, Shanghai, China
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Neurosurgical Institute of Fudan University, Shanghai, China
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Department of Neurosurgery, Huashan Hospital North, Fudan University, Shanghai, China
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Neurosurgical Institute of Fudan University, Shanghai, China
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Department of Neurosurgery, Huashan Hospital North, Fudan University, Shanghai, China
- Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China
- Neurosurgical Institute of Fudan University, Shanghai, China
- Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China
- Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China
- Department of Neurosurgery, Huashan Hospital North, Fudan University, Shanghai, China
Keywords:
Epidemiology, genetic characteristics, Moyamoya disease, neuroimaging, pathogenesis, progression, treatment.
Abstract: Moyamoya disease (MMD) is a chronic cerebrovascular disease characterized by progressive
stenosis of the arteries of the circle of Willis, with the formation of collateral vascular network
at the base of the brain. Its clinical manifestations are complicated. Numerous studies have attempted
to clarify the clinical features of MMD, including its epidemiology, genetic characteristics,
and pathophysiology. With the development of neuroimaging techniques, various neuroimaging
modalities with different advantages have deepened the understanding of MMD in terms of structural,
functional, spatial, and temporal dimensions. At present, the main treatment for MMD focuses on
neurological protection, cerebral blood flow reconstruction, and neurological rehabilitation, such as
pharmacological treatment, surgical revascularization, and cognitive rehabilitation. In this review,
we discuss recent progress in understanding the clinical features, in the neuroimaging evaluation
and treatment of MMD.