Title:Synopsis of Pharmotechnological Approaches in Diagnostic and Management Strategies for Fighting Against COVID-19
Volume: 27
Issue: 39
Author(s): Asim Azhar*, Nazia Hassan, Manvi Singh, Khaled Al-Hosaini*Md. Amjad Kamal*
Affiliation:
- Aligarh College of Education, Aligarh, Uttar Pradesh,India
- Department of Pharmacology & Toxicology, College of Pharmacy, King Saud University, Post Box 2457, Riyadh 11451,Saudi Arabia
- West China School of Nursing/Institutes for Systems Genetics, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, Sichuan,China
Keywords:
ACE2, biosensors, COVID-19, nanoparticles, pharmotechnological, SARS-CoV-2, TMPRSS2.
Abstract: Nanoparticles (NPs) are projected to play a significant role in the fight against coronavirus disease
(COVID-19). The various properties of NPs like magnetic and optical can be exploited to build diagnostic test
kits. The unembellished morphological and physiochemical resemblances of SARS-CoV-2 with synthetic NPs
make them a potent tool for mediation. Nanoparticles can be analytically functionalized with different proteins,
polymers, and functional groups to perform specific inhibitory functions, while also serving as delivery vehicles.
Moreover, NPs can also be employed to prepare broad-spectrum respiratory drugs and vaccines that can
guard seasonal flu and prepare the human race for the pandemic in the future. The present review outlines the
role of NPs for detection, diagnostic and therapeutic purposes against members of the coronavirus family. We
emphasize nanomaterial-based approaches to address coronaviruses in general and SARS-CoV-2 in particular.
We discuss NPs based detection systems like graphene (G-FET), biosensors, and plasmonic photothermal associated
sensors. The therapeutic approaches exploiting NPs such as inorganic, organic virus-like & self-assembly
protein (VLP), and inactivation of SARS-CoV-2 employing photodynamic are also presented.
