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摘要
目的:锯齿状结肠病变是一组表面上皮和隐窝呈锯齿状(锯齿状)的结肠病变,其特殊的分子和遗传发育机制尚不完全清楚。这些地层因其癌前潜能而引起关注。 目的:综述结肠和阑尾的锯齿状病变。我们的重点是现代分类,在癌变中的作用,以及形态学诊断的新方法。 方法:使用PubMed、Scopus、ResearchGate、谷歌、MEDLINE和ScienceDirect数据库进行文献检索,以查找2000年至2020年发表的涉及流行病学风险因素的锯齿状结直肠病变相关癌症的研究。潜在的病理生理机制,并使我们能够回顾这些因素以及分子,遗传学和结构模式。 结果:在病理学家的实践中,锯齿状结肠病变占结肠所有良性肿瘤的三分之一。对锯齿状病变的研究始于20世纪。在2019年更新的分类中,术语和诊断标准发生了变化。本文综述了形态学标准、免疫组化和分子图谱、内窥镜和临床特征。 结论:尽管我们在提高对结直肠锯齿状息肉的认识和诊断标准方面做出了很大的努力,但与21世纪初对肿瘤前锯齿状病变的最初形态学描述相比,几乎没有什么改变。仍然需要更多的研究,以开发更明确的免疫表型和分子生物标记,以区分非肿瘤性和肿瘤性锯齿状病变。
关键词: 锯齿状结直肠病变,肿瘤,结肠,阑尾,形态学标准,免疫组化。
Current Medicinal Chemistry
Title:Colorectal Serrated Lesions: A Current View on Clinical, Morphological, Molecular, and Genetic Diagnostic Criteria
Volume: 28 Issue: 41
关键词: 锯齿状结直肠病变,肿瘤,结肠,阑尾,形态学标准,免疫组化。
摘要:
Objective: Serrated colorectal lesions are a group of colonic lesions with a serrated (saw-tooth) profile of the surface epithelium and crypts, and peculiar molecular and genetic developmental mechanisms that are incompletely understood. These formations cause concern due to their premalignant potential.
Aim: The review is dedicated to serrated lesions of colon and appendix. We focused on modern classification, role in carcinogenesis, as well as new approaches to morphological diagnosis.
Methods: A literature search was performed using PubMed, Scopus, ResearchGate, Google, MEDLINE, and ScienceDirect databases to find studies of serrated colorectal lesions related cancer published between 2000 and 2020 that address epidemiological risk factors, underlying pathophysiological mechanism and enable our review of these factors as well as molecular, genetics, and structural patterns.
Results: Serrated colorectal lesions take one third of all benign neoplasms of the colon in the pathologist’s practice. The active study of serrated lesions began in the 1900s. Terminology and diagnostic criteria changed in the updated classification in 2019. Morphological criteria, immunohistochemical and molecular profile, endoscopic and clinical characteristics are reviewed.
Conclusion: Although significant efforts were made in attempt to improve our understanding and diagnostic criteria of serrated polyps of colorectum, very little has changed since the original morphologic description of preneoplastic serrated lesions in early 2000s. There remains a need for more research in order to develop more definitive immuophenotypic and molecular biomarkers in order to distinguish between non-neoplastic and neoplastic serrated lesions.
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Cite this article as:
Colorectal Serrated Lesions: A Current View on Clinical, Morphological, Molecular, and Genetic Diagnostic Criteria, Current Medicinal Chemistry 2021; 28 (41) . https://dx.doi.org/10.2174/0929867328666210715125428
DOI https://dx.doi.org/10.2174/0929867328666210715125428 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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