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摘要
低温等离子体(LTP)是一种包含电子、离子、自由基、光等的部分电离气体。近年来,低温等离子体的生物医学应用已成为等离子体科学和生物科学研究的热点。等离子体治疗癌症是等离子体生物医学应用中最具挑战性的课题。许多体外和体内实验研究了LTP的抗肿瘤作用。血浆活化溶液中的细胞外活性氧和氮物种(RONS)是抗肿瘤作用的关键因素,而LTP的氨基酸修饰可能会影响细胞反应。细胞内的RONS也是抗肿瘤作用的关键因素。多种信号通路,如p53信号通路、生存和增殖信号通路、氧化应激依赖的信号通路等都被LTP激活。
关键词: 低温等离子体、等离子体医学、等离子体癌症治疗、活性氧(ROS)、生化网络、等离子体活化介质。
Current Medicinal Chemistry
Title:Cancer Treatments Using Low-Temperature Plasma
Volume: 28 Issue: 41
关键词: 低温等离子体、等离子体医学、等离子体癌症治疗、活性氧(ROS)、生化网络、等离子体活化介质。
摘要: Low-temperature plasma (LTP) is a partially ionized gas that contains electrons, ions, radicals, light, etc. Recently, the bio-medical application of LTP has become a hot topic in plasma science and biological science. Cancer treatment with plasma is the most challenging topic in plasma bio-medical applications. Many in vitro and in vivo experiments have been conducted to investigate the anti-tumor effects of LTP. Extracellular reactive oxygen and nitrogen species (RONS) in plasma-activated solutions are key factors for the anti-tumor effects, and amino acid modifications by LTP may affect cellular responses. Intracellular RONS are also key factors for the anti-tumor effects. Various signaling pathways, such as p53 signaling pathways, survival and proliferation signaling pathways, and oxidative stress-dependent signaling pathways are activated by LTP.
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Cite this article as:
Cancer Treatments Using Low-Temperature Plasma, Current Medicinal Chemistry 2021; 28 (41) . https://dx.doi.org/10.2174/0929867328666210629121731
DOI https://dx.doi.org/10.2174/0929867328666210629121731 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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