Title:Cancer Treatments Using Low-Temperature Plasma
Volume: 28
Issue: 41
Author(s): Hiromasa Tanaka*, Masaaki Mizuno, Kenji Ishikawa, Shinya Toyokuni, Hiroaki Kajiyama, Fumitaka Kikkawa and Masaru Hori
Affiliation:
- Institute of Innovation for Future Society, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan
Keywords:
Low-temperature plasma, plasma medicine, plasma cancer therapy, reactive oxygen species (ROS), biochemical networks, plasma-activated medium.
Abstract: Low-temperature plasma (LTP) is a partially ionized gas that contains electrons,
ions, radicals, light, etc. Recently, the bio-medical application of LTP has become
a hot topic in plasma science and biological science. Cancer treatment with plasma is the
most challenging topic in plasma bio-medical applications. Many in vitro and in vivo experiments
have been conducted to investigate the anti-tumor effects of LTP. Extracellular
reactive oxygen and nitrogen species (RONS) in plasma-activated solutions are key factors
for the anti-tumor effects, and amino acid modifications by LTP may affect cellular
responses. Intracellular RONS are also key factors for the anti-tumor effects. Various signaling
pathways, such as p53 signaling pathways, survival and proliferation signaling
pathways, and oxidative stress-dependent signaling pathways are activated by LTP.
