Title:Structures, Synthesis and Biological Activities of Nonactic Acid and Its
Derivatives
Volume: 28
Issue: 42
Author(s): Jianan Hu, Jirui Zhang and Jian He*
Affiliation:
- Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical
University, 1838 Guangzhou Avenue North; Guangzhou 510515, PR China
Keywords:
(±)-Nonactic acid, nonactin subunits, homononactic acid, chiral synthesis, biological activities, structure- activity relationship.
Abstract: Nonactic acid, which is a macrocyclic nonactin subunit, contains four asymmetric
centers and has the molecular formula of C10H18O3. Due to their various biological activities
and challenging structural characteristics, nonactic acid and its derivatives have attracted
much attention from scientists since 1955. These compounds possess significant antibacterial,
insecticidal and acaricidal activities, as well as a promoting effect on plant growth. However,
the studies in the anticancer activities of these compounds are limited. It is noticed that some
derivatives of nonactic acid show significant cytotoxicity toward different human cancer cells,
from which, a basic structure-activity relationship might be able to obtain. On the basis of
these progresses, we believe that this review may provide new ideas for generating potent
anticancer compounds bearing the same pharmacophores derived from those macrocyclic
molecules.
