Title:Molecular Targets of Cannabinoids Associated with Depression
Volume: 29
Issue: 11
关键词:
大麻素,分子靶点,抑郁,CB受体,MAO,NMDA受体,GABA受体,CCK受体。
摘要: Novel therapeutic strategies are needed to address depression, a major neurological
disorder affecting hundreds of millions of people worldwide. Cannabinoids and their synthetic
derivatives have demonstrated numerous neurological activities and may have the potential to
be developed into new treatments for depression. This review highlights cannabinoid (CB)
receptors, monoamine oxidase (MAO), N-methyl-D-aspartate (NMDA) receptor, gammaaminobutyric
acid (GABA) receptor, and cholecystokinin (CCK) receptor as key molecular
targets of cannabinoids that are associated with depression. The anti-depressant activity of
cannabinoids and their binding modes with cannabinoid receptors are discussed, providing
insights into rational design and discovery of new cannabinoids or cannabimimetic agents
with improved druggable properties.