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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Research Article

Characterization of Bioactive Compounds from the Red Sea Tunicate- Derived Fungus Penicillium commune DY004

Author(s): Diaa T.A. Youssef*, Lamiaa A. Shaala, Ameen Almohammadi, Sameh S. Elhady, Torki A. Alzughaibi and Khalid Z. Alshali

Volume 19, Issue 2, 2022

Published on: 17 June, 2021

Page: [144 - 149] Pages: 6

DOI: 10.2174/1570178618666210617112441

Price: $65

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Abstract

As a part of our ongoing interest to identify bioactive microbial secondary metabolites, the Red Sea tunicate derived Penicillium commune DY004 was investigated. A new dipeptide, penicillizine A (1) together with cyclo(L-Pro-L-Phe) (2), meleagrin (3), α-cyclopiazonic acid (4) and N-(4-hydroxyphenethyl)acetamide (5) was isolated from the ethyl acetate extract of the cultures of the fungus. The structural determinations of 1-5 were supported by interpretation of their oneand two-dimensional nuclear magnetic resonance (NMR) and mass spectrometry (MS) data. In the evaluation of the compounds for their effects against three human tumorous cell lines, meleagrin (3) and α-cyclopiazonic acid (4) displayed the highest and potent activity against HeLa, U373 glioblastoma and MDA-MB-231 cell lines down up to 3.1 μg/mL. These results suggest that marine fungi are a copious source of drug leads with therapeutic potential. Meleagrin and α-cyclopiazonic acid could be used as potential scaffolds for the development of new and more effective drug leads.

Keywords: Red Sea Didemnum species, Penicillium commune DY004, penicillizine A, cyclo (l-Pro-l-Phe), meleagrin, α-cyclopiazonic acid, structural determination, human cancer cell lines.

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