Title:Zn(OAc)2•2H2O-Catalyzed Betti Base Synthesis under Solvent-free Conditions
Volume: 19
Issue: 1
Author(s): M. Mujahid Alam, Hari B. Bollikolla and Ravi Varala*
Affiliation:
- Scrips Pharma,
Mallapur, Hyderabad-500 076, Telangana, India
Keywords:
Betti base, zinc acetate dehydrate (Zn(OAc)2•2H2O), catalysis, multicomponent synthesis, β-naphthol, amines and solvent-free conditions.
Abstract: Zn(OAc)2•2H2O-catalyzed one-pot multicomponent reaction of Betti bases using β-
naphthol, aldehydes, and amines, under neat conditions in moderate to excellent yields (68-
96%) is reported in this study. This synthetic protocol offers several advantages, such as operational
simplicity, shorter reaction period, high yields, and easy work-up procedures.