Title:New Small-molecule Analgesics
Volume: 28
Issue: 30
关键词:
镇痛药、镇痛药、非甾体抗炎药、环氧合酶抑制剂、阿片类镇痛药、阿片受体、镇痛佐剂、受体配体。
摘要: Pain is a symptom of ninety percent of human diseases, and pain management is a
very important medicinal problem. Various modulators of the pain response have been detected,
and analgesic effects are obtained by increasing inhibition or decreasing excitation in
the nervous system. Various known analgesic drugs are commonly used to relieve the pain;
however, this problem is still not fully resolved by currently available treatments. Available
analgesic drugs (non-steroidal anti-inflammatory drugs, opioids and analgesic adjuvants) are
not too effective and are severely limited by adverse effects, for example, opioid addiction.
Therefore, developing effective pain management is a difficult but necessary task. Thus,
there is an urgent need for further development of the design and synthesis of new analgesic
agents. The aim of this review is to present recent progress in search of new small molecule
analgesics. The structures and effects of new perspective analgesic agents (anti-inflammatory
agents, opioid analgesics, adjuvant agents for pain management, and natural compounds) are
presented and discussed. The review covers the literature published in 2015-2020 years and
includes 173 references.
