Title:An Overview of Zinc Oxide Nanoparticles Produced by Plant Extracts
for Anti-tuberculosis Treatments
Volume: 29
Issue: 1
关键词:
抗结核，耐药，结核分枝杆菌，植物提取物，结核，金属氧化物纳米颗粒，ZnO纳米颗粒。
摘要: Tuberculosis (TB), induced by Mycobacterium tuberculosis (MTB), is a fatal infectious
disease that kills millions of lives worldwide. The emergence of drug-resistant and multidrug-resistant
cases is regarded as one of the most challenging threats to TB control due to the low cure rate. Therefore,
TB and drug-resistant TB epidemic urge us to explore more effective therapies. The increasing
knowledge of nanotechnology has extended the use of some nanomedicines for disease treatment in
clinics, which also provide novel possibilities for nano-based medicines for TB treatment. Zinc oxide
nanoparticles (ZnO NPs) have gained increasing attention for anti-bacterial uses based on their strong
ability to induce reactive oxidative species (ROS) and release bactericidal Zinc ions (Zn2+), which are
expected to act as novel strategies for TB and drug-resistant TB treatment. Some plant extracts, always
from active herbal medicines, have been widely reported to show attractive anti-bacterial activity for
infectious treatment, including TB. Here, we summarize the synthesis of ZnO NPs using plant extracts
(green synthesized ZnO NPs), and further discuss their potentials for anti-TB treatments. This is the
first review article discussing the anti-TB activity of ZnO NPs produced using plant extracts, which
might contribute to the further applications of green synthesized ZnO NPs for anti-TB and drugresistant
TB treatment
