Title:Protective Effects of Curcumin against Lipopolysaccharide-Induced Toxicity
Volume: 28
Issue: 33
关键词:
姜黄素、脂多糖、姜黄、感染性休克、炎症、细胞因子、白细胞介素。
摘要:
Background: Lipopolysaccharide (LPS), a Gram-negative bacterial cell wall
component, evokes intensive inflammatory responses in the human body. Naturally, inflammation
is a part of the host immune response to an infection; nonetheless, an exaggerated
response can lead to a series of pathophysiological consequences, collectively
known as LPS toxicity or septic shock.
Objective: This review will explore the cellular and experimental investigations that
mainly focus on Curcumin's therapeutic effects on the LPS-mediated inflammatory responses.
Method: A literature review of all relevant studies was performed.
Conclusion: Curcumin has been reported to exert anti-inflammatory properties by interfering
with LPS-induced inflammatory pathways, including binding to cell surface receptors
of LPS, NF-kB activation pathway, and inflammasome activation. Further clinical
studies on the effect of Curcumin in reducing the pathophysiological consequences of
LPS toxicity would substantiate the use of this molecule for future therapeutic approaches.
