Title:Flavonoids, the Family of Plant-Derived Antioxidants Making Inroads into
Novel Therapeutic Design Against Ionizing Radiation-Induced Oxidative
Stress in Parkinson’s Disease
Volume: 20
Issue: 2
Author(s): Tapan Behl*, Gagandeep Kaur, Aayush Sehgal, Gokhan Zengin, Sukhbir Singh, Amirhossein Ahmadi and Simona Bungau
Affiliation:
- Chitkara College of Pharmacy, Chitkara University, Punjab, Chandigarh, India
Keywords:
Parkinson’s disease, ionizing radiation, oxidative stress, ROS, flavonoids, antioxidants.
Abstract:
Background: Ionizing radiation from telluric sources is unceasingly an unprotected pitfall
to humans. Thus, the foremost contributors to human exposure are global and medical radiations.
Various evidences assembled during preceding years reveal the pertinent role of ionizing radiation-
induced oxidative stress in the progression of neurodegenerative insults, such as Parkinson’s
disease, which have been contributing to increased proliferation and generation of reactive oxygen
species.
Objective: This review delineates the role of ionizing radiation-induced oxidative stress in Parkinson’s
disease and proposes novel therapeutic interventions of flavonoid family, offering effective
management and slowing down the progression of Parkinson’s disease.
Methods: Published papers were searched in MEDLINE, PubMed, etc., published to date for indepth
database collection.
Results: The oxidative damage may harm the non-targeted cells. It can also modulate the functions
of the central nervous system, such as protein misfolding, mitochondria dysfunction, increased levels
of oxidized lipids, and dopaminergic cell death, which accelerate the progression of Parkinson’s
disease at the molecular, cellular, or tissue levels. In Parkinson’s disease, reactive oxygen species
exacerbate the production of nitric oxides and superoxides by activated microglia, rendering death
of dopaminergic neuronal cell through different mechanisms.
Conclusion: Rising interest has extensively engrossed in the clinical trial designs based on the
plant-derived family of antioxidants. They are known to exert multifarious impact on neuroprotection
via directly suppressing ionizing radiation-induced oxidative stress and reactive oxygen species
production or indirectly increasing the dopamine levels and activating the glial cells.
