Title:Revisiting the Antiviral Efficacy of Terpenoids: Plausible Adjunct Therapeutics
for Novel SARS-CoV-2?
Volume: 21
Issue: 12
Author(s): Afza Ahmad, Rohit Kumar Tiwari and Irfan Ahmad Ansari*
Affiliation:
- Department of Biosciences, Integral University, Kursi Road, Lucknow, Uttar Pradesh-226026,India
Keywords:
SARS-CoV-2, terpenoids, anti-viral, therapeutic, management and bioactive constituents.
Abstract: Presently the world is witnessing the most devastating pandemic in the history of
mankind caused by Severe Acute Respiratory Syndrome or SARS-CoV-2. This dreaded pandemic
is responsible for escalated mortality rates across the globe and this is the worst catastrophe in the
history of mankind. Since its outbreak, substantial scientific explorations focusing on the formulation
of novel therapeutical and/or adjunct intervention against the disease are continuously in the
pipeline. However, till date, no effective therapy has been approved and hence the present alarming
situation urges the necessity of exploring novel, safe and efficient interventional strategies. Functionally,
terpenoids are a class of secondary plant metabolites having multi facet chemical structures
and are categorically documented to be the largest reservoir of bioactive constituents, predominant
in nature. Intriguingly, very little is scientifically explored or reviewed in regards to the anti-CoV-2
attributes of terpenoids. The present article thus aims to revisit the antiviral efficacy of terpenoids
by reviewing the current scientific literature and thereby provide an opinion on the plausibility of
exploring them as potential therapeutical intervention to deal with ongoing CoV-2 pandemic.
