Title:An Updated Review of the Cross-talk Between MicroRNAs and Epigenetic
Factors in Cancers
Volume: 28
Issue: 42
Author(s): Narges Dastmalchi , Reza Safaralizadeh*, Seyed Mahdi Banan Khojasteh, Mohammad Reza Sam, Saeid Latifi-Navid, Bashdar Mahmud Hussen, Mahdi Abdoli Shadbad and Behzad Baradaran*
Affiliation:
- Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
- Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Keywords:
Cancer, microRNA, epigenetic, modulatory circuit, protien coding genes, tumor progression.
Abstract:
Background: Growing evidence indicates that miRs have critical activities in
adjusting cellular processes, e.g., cell death, proliferation, and cell-cycle.
Introduction: This study aimed to provide a concise review of the recent findings regarding
tumoral miRs and the cross-talk between miRs and epigenetic factors.
Results: Like the protein-coding genes, the expression levels of miRs are mediated by
various transcriptional networks. Indeed, the expression of miRs could be epigenetically
modulated by DNA methylation factors and histone modifiers. Furthermore, miRs can
suppress critical factors, which mediate epigenetic modifications. Besides, miRs have
been implicated in cancer development, metastasis, and chemo-resistance. The aberrant
expression of miRs and dysregulated modulatory circuits between miRs and epigenetic
factors participate in tumor progression.
Conclusion: Identifying tumoral miRs can provide ample opportunity to overcome chemo-
resistance and bring a forefront treatment for affected patients.
