摘要
由于大量摄入橄榄油、坚果、红酒、豆类、水果和蔬菜,所有基本元素都富含抗氧化物质和多酚,地中海饮食被全世界公认为营养的良好原型。多酚是广泛的植物化学物质和/或合成化合物,已被证明对人类健康有益。在本综述中,我们批判性地总结了橄榄和特级初榨橄榄油中所含多酚以及白藜芦醇(一种非类黄酮酚类化合物)的充分表征的抗氧化和抗炎特性。我们讨论了这些多酚作为治疗人类疾病的药物制剂的潜在用途。我们还展示了它们在预防和管理重要的神经退行性疾病(酒精相关的脑部疾病和衰老)和神经肌肉疾病(脊髓性肌萎缩症和肌萎缩侧索硬化症和杜兴氏肌营养不良症)方面的新兴重要性,其中氧化应激起着重要作用主导作用。
关键词: 橄榄多酚、白藜芦醇、微生物群、衰老、酒精相关的脑部疾病、SMA、ALS、DMD。
Current Medicinal Chemistry
Title:Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders
Volume: 28 Issue: 37
关键词: 橄榄多酚、白藜芦醇、微生物群、衰老、酒精相关的脑部疾病、SMA、ALS、DMD。
摘要: The Mediterranean diet is worldwide recognized as a good prototype of nutrition due to the conspicuous intake of olive oil, nuts, red wine, legumes, fruit, and vegetables, all fundamental elements rich in antioxidant substances and polyphenols. Polyphenols are a wide range of phytochemicals and/or synthetic chemical compounds with proven beneficial properties for human health. In the present review, we critically summarize the wellcharacterized antioxidant and anti-inflammatory properties of polyphenols contained in the olives and extra virgin olive oil and of resveratrol, a non-flavonoid phenolic compound. We discuss the potential use of these polyphenols as pharmaceutical formulations for the treatment of human diseases. We also show the emerging importance of their consumption in the prevention and management of crucial neurodegenerative conditions (alcohol-related brain disorders and aging) and in neuromuscular disorders (Spinal Muscular Atrophy and Amyotrophic Lateral Sclerosis and Duchenne Muscular Dystrophy), where oxidative stress plays a predominant role.
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Cite this article as:
Mediterranean Diet, Brain and Muscle: Olive Polyphenols and Resveratrol Protection in Neurodegenerative and Neuromuscular Disorders, Current Medicinal Chemistry 2021; 28 (37) . https://dx.doi.org/10.2174/0929867328666210504113445
DOI https://dx.doi.org/10.2174/0929867328666210504113445 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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