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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Review Article

Immunotherapy for Breast Cancer Treatment: Current Evidence and Therapeutic Options

Author(s): Kavita Singh, Dhananjay Yadav, Meenu Jain, Pramod Kumar Singh and Jun-O Jin*

Volume 22, Issue 2, 2022

Published on: 19 January, 2022

Page: [212 - 224] Pages: 13

DOI: 10.2174/1871530321666210426125904

Price: $65

Abstract

Breast Cancer (BC) has the highest incidence among all forms of malignancies detected in women globally. The therapeutic approaches available for BC include chemotherapy, radiation therapy, hormonal therapy, and surgery. Recently, advanced immunology-based therapeutics with potential for BC treatment, including immune checkpoint blockades, vaccines, and combinations with other treatment strategies, have emerged. Although commonly used treatments such as trastuzumab/ pertuzumab for human epidermal growth factor receptor 2-positive BC and hormone therapy for estrogen receptor-positive and/or progesterone receptor-positive BC are specific, triple-negative BC cases remain a great challenge for treatment measures. Immune checkpoint inhibitors (anti- PD-1/anti-CTLA-4) and anti-cancer vaccines (NeuVax, MUC-1, AVX901, INO-1400, and CEA), either alone or in combination with other therapies, represent a new paradigm in cancer therapeutics. In this review, we highlight the current immunotherapeutic aspects and ongoing trials aimed at the development of better treatment regimens for BC.

Keywords: Immunotherapy, immune check point blockades, cancer vaccine, breast cancer, estrogen receptor, progesterone.

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